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Induced effects of transcranial magnetic stimulation on the autonomic nervous system and the cardiac rhythm.

Cabrerizo M, Cabrera A, Perez JO, de la Rua J, Rojas N, Zhou Q, Pinzon-Ardila A, Gonzalez-Arias SM, Adjouadi M - ScientificWorldJournal (2014)

Bottom Line: The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases.Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio.The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

View Article: PubMed Central - PubMed

Affiliation: Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, College of Engineering and Computing, Florida International University (FIU), USA.

ABSTRACT
Several standard protocols based on repetitive transcranial magnetic stimulation (rTMS) have been employed for treatment of a variety of neurological disorders. Despite their advantages in patients that are retractable to medication, there is a lack of knowledge about the effects of rTMS on the autonomic nervous system that controls the cardiovascular system. Current understanding suggests that the shape of the so-called QRS complex together with the size of the different segments and intervals between the PQRST deflections of the heart could predict the nature of the different arrhythmias and ailments affecting the heart. This preliminary study involving 10 normal subjects from 20 to 30 years of age demonstrated that rTMS can induce changes in the heart rhythm. The autonomic activity that controls the cardiac rhythm was indeed altered by an rTMS session targeting the motor cortex using intensity below the subject's motor threshold and lasting no more than 5 minutes. The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases. Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio. The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

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Related in: MedlinePlus

rTMS protocol implemented for all subjects. Note that 5 stimuli were applied during intervals of 1 minute of duration.
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Related In: Results  -  Collection


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fig2: rTMS protocol implemented for all subjects. Note that 5 stimuli were applied during intervals of 1 minute of duration.

Mentions: The rTMS protocol implemented for all subjects is as described in Figure 2, where trains of stimuli of 1-second duration at 10 Hz were applied to four different electrode locations (F1L, F2L, F1R, and F2R) on the scalp; as a total, 50 pulses were delivered to each brain location, as the train of pulses was repeated 5 times at intervals of 1 minute (interstimulus time: 59 seconds). The intensity of the magnetic pulses was below the visual motor response in the hand. An initial blood pressure was obtained and an ECG signal was recorded for 5 minutes as baseline measurements. These same measurements were also collected at the end of a 5-minute session of brain stimulation to assess the difference in these measurements between baseline and after brain stimulation.


Induced effects of transcranial magnetic stimulation on the autonomic nervous system and the cardiac rhythm.

Cabrerizo M, Cabrera A, Perez JO, de la Rua J, Rojas N, Zhou Q, Pinzon-Ardila A, Gonzalez-Arias SM, Adjouadi M - ScientificWorldJournal (2014)

rTMS protocol implemented for all subjects. Note that 5 stimuli were applied during intervals of 1 minute of duration.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4127210&req=5

fig2: rTMS protocol implemented for all subjects. Note that 5 stimuli were applied during intervals of 1 minute of duration.
Mentions: The rTMS protocol implemented for all subjects is as described in Figure 2, where trains of stimuli of 1-second duration at 10 Hz were applied to four different electrode locations (F1L, F2L, F1R, and F2R) on the scalp; as a total, 50 pulses were delivered to each brain location, as the train of pulses was repeated 5 times at intervals of 1 minute (interstimulus time: 59 seconds). The intensity of the magnetic pulses was below the visual motor response in the hand. An initial blood pressure was obtained and an ECG signal was recorded for 5 minutes as baseline measurements. These same measurements were also collected at the end of a 5-minute session of brain stimulation to assess the difference in these measurements between baseline and after brain stimulation.

Bottom Line: The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases.Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio.The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

View Article: PubMed Central - PubMed

Affiliation: Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, College of Engineering and Computing, Florida International University (FIU), USA.

ABSTRACT
Several standard protocols based on repetitive transcranial magnetic stimulation (rTMS) have been employed for treatment of a variety of neurological disorders. Despite their advantages in patients that are retractable to medication, there is a lack of knowledge about the effects of rTMS on the autonomic nervous system that controls the cardiovascular system. Current understanding suggests that the shape of the so-called QRS complex together with the size of the different segments and intervals between the PQRST deflections of the heart could predict the nature of the different arrhythmias and ailments affecting the heart. This preliminary study involving 10 normal subjects from 20 to 30 years of age demonstrated that rTMS can induce changes in the heart rhythm. The autonomic activity that controls the cardiac rhythm was indeed altered by an rTMS session targeting the motor cortex using intensity below the subject's motor threshold and lasting no more than 5 minutes. The rTMS activation resulted in a reduction of the RR intervals (cardioacceleration) in most cases. Most of these cases also showed significant changes in the Poincare plot descriptor SD2 (long-term variability), the area under the low frequency (LF) power spectrum density curve, and the low frequency to high frequency (LF/HF) ratio. The RR intervals changed significantly in specific instants of time during rTMS activation showing either heart rate acceleration or heart rate deceleration.

Show MeSH
Related in: MedlinePlus