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Vanadium methyl-bipyridine organoligand and its influence on energy balance and organs mass.

Krośniak M, Francik R, Wojtanowska-Krośniak A, Tedeschi C, Krasoń-Nowak M, Chłopicka J, Gryboś R - Biol Trace Elem Res (2014)

Bottom Line: Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects.The kJ/g ratio which describes this process has been calculated.The application of the tested vanadium compound results also in the statistical decrease of the fatty liver caused by fructose and fat diet.

View Article: PubMed Central - PubMed

ABSTRACT
In the treatment of lifestyle diseases, including metabolic syndrome and type 2 diabetes, it is important to lower body mass and fat tissue, and consequently, to increase insulin-sensitivity. Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects. This paper discusses the influence of three diets-control, high-fructose, and high-fatty diet-on absorption of energy from food in order to transform it into body mass. The kJ/g ratio which describes this process has been calculated. In the tested diets, the addition of fructose (79.13 ± 2.47 kJ/g) or fat (82.48 ± 2.28 kJ/g) results in higher transformation of energy into body mass than in the case of control diet (89.60 ± 1.86 kJ/g). The addition of Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O (where 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine) results in statistical increase of that ratio: fructose diet (86.88 ± 0.44 kJ/g), fat diet (104.68 ± 3.01 kJ/g), and control diet (115.98 ± 0.56 kJ/g), respectively. Fat diet statistically influences the decrease of kidney mass in comparison to the other diets. The application of the tested vanadium compound results also in the statistical decrease of the fatty liver caused by fructose and fat diet.

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Chemical structure of 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine (Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O) used in present investigation
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Fig1: Chemical structure of 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine (Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O) used in present investigation

Mentions: Bisperoxo complex of vanadium (V)–Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O (MW = 481.94 g/mol). The synthesis was carried out by modified method described in literature [31]. Ten millimoles of NaVO3 was dissolved in molar excess of 10 % H2O2 (molar ratio of H2O2 to vanadium is equal 1:3). To the obtained clear yellow solution, cooled in the ice bath, 20 ml of ethanolic solution containing 10 mmol of proper 4,4′-Me2-2,2′-bpy (4,4′-dimethyl-2,2′-bipyridine) was added dropwise with constant stirring. Temperature of the reaction mixture did not exceed 10 °C during the synthesis. Afterwards, 50 ml of cooled ethanol was added to precipitate yellow crystals. The solid phase was filtered off via a glass frit and washed with 10 ml of cold ethanol. Obtained vanadium complex was dried in the air, in a dark place, for 24 h, then it was collected and stored in the refrigerator. Purity of obtained complex was confirmed by microanalysis, spectroscopic methods: 1H NMR and IR. The structure of complex anion is presented in Fig. 1.Fig. 1


Vanadium methyl-bipyridine organoligand and its influence on energy balance and organs mass.

Krośniak M, Francik R, Wojtanowska-Krośniak A, Tedeschi C, Krasoń-Nowak M, Chłopicka J, Gryboś R - Biol Trace Elem Res (2014)

Chemical structure of 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine (Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O) used in present investigation
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4127192&req=5

Fig1: Chemical structure of 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine (Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O) used in present investigation
Mentions: Bisperoxo complex of vanadium (V)–Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O (MW = 481.94 g/mol). The synthesis was carried out by modified method described in literature [31]. Ten millimoles of NaVO3 was dissolved in molar excess of 10 % H2O2 (molar ratio of H2O2 to vanadium is equal 1:3). To the obtained clear yellow solution, cooled in the ice bath, 20 ml of ethanolic solution containing 10 mmol of proper 4,4′-Me2-2,2′-bpy (4,4′-dimethyl-2,2′-bipyridine) was added dropwise with constant stirring. Temperature of the reaction mixture did not exceed 10 °C during the synthesis. Afterwards, 50 ml of cooled ethanol was added to precipitate yellow crystals. The solid phase was filtered off via a glass frit and washed with 10 ml of cold ethanol. Obtained vanadium complex was dried in the air, in a dark place, for 24 h, then it was collected and stored in the refrigerator. Purity of obtained complex was confirmed by microanalysis, spectroscopic methods: 1H NMR and IR. The structure of complex anion is presented in Fig. 1.Fig. 1

Bottom Line: Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects.The kJ/g ratio which describes this process has been calculated.The application of the tested vanadium compound results also in the statistical decrease of the fatty liver caused by fructose and fat diet.

View Article: PubMed Central - PubMed

ABSTRACT
In the treatment of lifestyle diseases, including metabolic syndrome and type 2 diabetes, it is important to lower body mass and fat tissue, and consequently, to increase insulin-sensitivity. Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects. This paper discusses the influence of three diets-control, high-fructose, and high-fatty diet-on absorption of energy from food in order to transform it into body mass. The kJ/g ratio which describes this process has been calculated. In the tested diets, the addition of fructose (79.13 ± 2.47 kJ/g) or fat (82.48 ± 2.28 kJ/g) results in higher transformation of energy into body mass than in the case of control diet (89.60 ± 1.86 kJ/g). The addition of Na[VO(O2)2(4,4′-Me2-2,2′-bpy)]•8H2O (where 4,4′-Me2-2,2′-bpy = 4,4′-dimethyl-2,2′-bipyridine) results in statistical increase of that ratio: fructose diet (86.88 ± 0.44 kJ/g), fat diet (104.68 ± 3.01 kJ/g), and control diet (115.98 ± 0.56 kJ/g), respectively. Fat diet statistically influences the decrease of kidney mass in comparison to the other diets. The application of the tested vanadium compound results also in the statistical decrease of the fatty liver caused by fructose and fat diet.

Show MeSH
Related in: MedlinePlus