Limits...
Relationship between bladder cancer and total fluid intake: a meta-analysis of epidemiological evidence.

Bai Y, Yuan H, Li J, Tang Y, Pu C, Han P - World J Surg Oncol (2014)

Bottom Line: A random-effect model was used to summarize the estimates of odds ratio (OR) with 95% confidence intervals (CI).In the subgroup analyses, the overall ORs for coffee, green, and black tea intake were 1.17 (95% CI: 1.03-1.33), 0.76 (95% CI: 0.66-0.95), and 0.80 (95% CI: 0.65-0.97), respectively.A significantly decreased risk was observed in Asian people (OR 0.27; 95% CI: 0.10-0.72).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang#37, Chengdu, Sichuan 610041, China. hanpingwch@163.com.

ABSTRACT

Objectives: Epidemiological findings regarding the association between total fluid intake and bladder cancer risk have yielded varying results. Our objective is to examine the possible associations between total fluid intake and bladder cancer risk.

Methods: Databases searched include the EMBASE and PUBMED, from inception to February 2014, with no limits on study language. We also reviewed the reference lists of identified studies. Stratified analyses were performed. A random-effect model was used to summarize the estimates of odds ratio (OR) with 95% confidence intervals (CI).

Results: Overall,17 case-control and four cohort studies were included. The overall OR of bladder cancer for the highest versus the lowest fluid intake was 1.06 (95% CI: 0.88-1.27). In the subgroup analyses, the overall ORs for coffee, green, and black tea intake were 1.17 (95% CI: 1.03-1.33), 0.76 (95% CI: 0.66-0.95), and 0.80 (95% CI: 0.65-0.97), respectively. A significantly decreased risk was observed in Asian people (OR 0.27; 95% CI: 0.10-0.72). Among smokers, a suggestive inverse association was observed between total fluid intake and overall bladder cancer risk (OR 0.80; 95% CI: 0.62-1.02).

Conclusions: Although this meta-analysis suggested that greater consumption of fluid may have a protective effect on bladder cancer in Asian people, there was no convincing evidence on this association because of the limitations of the individual trials.

Show MeSH

Related in: MedlinePlus

Funnel plot of studies included evaluating the association between total fluid intake and bladder cancer risk. (S.E: Standard Error).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4127191&req=5

Figure 3: Funnel plot of studies included evaluating the association between total fluid intake and bladder cancer risk. (S.E: Standard Error).

Mentions: The results of qualitative assessment of the studies included in our meta-analysis were shown in Tables 1 and 2. All of them were given a score of 6 to 8 stars. There was no funnel plot asymmetry for the association between total fluid intake and risk of bladder cancer, P values for Begg’s adjusted rank correlation test was 0.244, and the Egger’s regression asymmetry test was 0.059, which suggested that there was no evidence of publication bias in this meta-analysis (Figure 3).


Relationship between bladder cancer and total fluid intake: a meta-analysis of epidemiological evidence.

Bai Y, Yuan H, Li J, Tang Y, Pu C, Han P - World J Surg Oncol (2014)

Funnel plot of studies included evaluating the association between total fluid intake and bladder cancer risk. (S.E: Standard Error).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4127191&req=5

Figure 3: Funnel plot of studies included evaluating the association between total fluid intake and bladder cancer risk. (S.E: Standard Error).
Mentions: The results of qualitative assessment of the studies included in our meta-analysis were shown in Tables 1 and 2. All of them were given a score of 6 to 8 stars. There was no funnel plot asymmetry for the association between total fluid intake and risk of bladder cancer, P values for Begg’s adjusted rank correlation test was 0.244, and the Egger’s regression asymmetry test was 0.059, which suggested that there was no evidence of publication bias in this meta-analysis (Figure 3).

Bottom Line: A random-effect model was used to summarize the estimates of odds ratio (OR) with 95% confidence intervals (CI).In the subgroup analyses, the overall ORs for coffee, green, and black tea intake were 1.17 (95% CI: 1.03-1.33), 0.76 (95% CI: 0.66-0.95), and 0.80 (95% CI: 0.65-0.97), respectively.A significantly decreased risk was observed in Asian people (OR 0.27; 95% CI: 0.10-0.72).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang#37, Chengdu, Sichuan 610041, China. hanpingwch@163.com.

ABSTRACT

Objectives: Epidemiological findings regarding the association between total fluid intake and bladder cancer risk have yielded varying results. Our objective is to examine the possible associations between total fluid intake and bladder cancer risk.

Methods: Databases searched include the EMBASE and PUBMED, from inception to February 2014, with no limits on study language. We also reviewed the reference lists of identified studies. Stratified analyses were performed. A random-effect model was used to summarize the estimates of odds ratio (OR) with 95% confidence intervals (CI).

Results: Overall,17 case-control and four cohort studies were included. The overall OR of bladder cancer for the highest versus the lowest fluid intake was 1.06 (95% CI: 0.88-1.27). In the subgroup analyses, the overall ORs for coffee, green, and black tea intake were 1.17 (95% CI: 1.03-1.33), 0.76 (95% CI: 0.66-0.95), and 0.80 (95% CI: 0.65-0.97), respectively. A significantly decreased risk was observed in Asian people (OR 0.27; 95% CI: 0.10-0.72). Among smokers, a suggestive inverse association was observed between total fluid intake and overall bladder cancer risk (OR 0.80; 95% CI: 0.62-1.02).

Conclusions: Although this meta-analysis suggested that greater consumption of fluid may have a protective effect on bladder cancer in Asian people, there was no convincing evidence on this association because of the limitations of the individual trials.

Show MeSH
Related in: MedlinePlus