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Oral cavity infection: an adverse effect after the treatment of oral cancer in aged individuals.

Pan J, Zhao J, Jiang N - J Appl Oral Sci (2014 Jul-Aug)

Bottom Line: In this study, the oral cavity microorganisms such as bacteria and yeast were taken for the analysis.Here, we used antimicrobial agents which are common in clinical practice.The oxacillin resistance of S. aureus isolate confirms that the prevalence of MRSA is increasing in accordance to age-factor and immune compromise in elderly patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthodontics, Shanghai Stomatological Disease Centre, Shanghai, China.

ABSTRACT

Objective: The immune compromised patients after treatment of oral cancer may have a chance of infection by drug-resistant opportunistic microbes. We investigated the occurrence of opportunistic microorganisms in aged individuals receiving follow-up examinations after treatment of oral cancer in China.

Material and methods: These patients were used as test group and the respective age grouped healthy individuals as control group. In this study, the oral cavity microorganisms such as bacteria and yeast were taken for the analysis. After the screening of representative microorganisms, their aptitude of pervasiveness against drugs was studied. Here, we used antimicrobial agents which are common in clinical practice. We also performed studies to investigate the presence of toxin genes in methicillin-resistant S. aureus (MRSA).

Results: The results indicate that the prevalence of drug-resistant microbes was more pronounced in oral cancer patients after initial treatment above 70 years old. The oxacillin resistance of S. aureus isolate confirms that the prevalence of MRSA is increasing in accordance to age-factor and immune compromise in elderly patients.

Conclusions: This study reveals the occurrence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer in aged individuals. Special attention should be directed to MRSA during the treatment of oral cancer, and to realize the fact of immune compromise in elderly patients.

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Related in: MedlinePlus

Graphical representation of the overall percentage of identified bacterialspecies
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f04: Graphical representation of the overall percentage of identified bacterialspecies

Mentions: The universal primers for bacteria, 16S rDNA sequencing was used for speciesidentification (Figure 4). The bacterialspecies isolated from the 78 participants (both groups) are identified asStaphylococcus (59%), Pseudomonas (53.8%),Streptococcus (44%), Neisseria (37.2%),Actinomyces (29.5%) and Veillonella (25.6),which are mostly found in the surgical scar and saliva. On comparison between twogroups of isolates, the Streptococcus, Staphylococcus, Pseudomonasand Neisseria showed significant differences (p<0.05) inpercentage of these species between groups I and II (Table 2). In Group I, the numbers of positive isolates of bacterialspecies were greater than that of the control group using traditional oral caremethods. For Veillonella and Actinomyces, nosignificant differences were shown between the two groups (Table 2).


Oral cavity infection: an adverse effect after the treatment of oral cancer in aged individuals.

Pan J, Zhao J, Jiang N - J Appl Oral Sci (2014 Jul-Aug)

Graphical representation of the overall percentage of identified bacterialspecies
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126820&req=5

f04: Graphical representation of the overall percentage of identified bacterialspecies
Mentions: The universal primers for bacteria, 16S rDNA sequencing was used for speciesidentification (Figure 4). The bacterialspecies isolated from the 78 participants (both groups) are identified asStaphylococcus (59%), Pseudomonas (53.8%),Streptococcus (44%), Neisseria (37.2%),Actinomyces (29.5%) and Veillonella (25.6),which are mostly found in the surgical scar and saliva. On comparison between twogroups of isolates, the Streptococcus, Staphylococcus, Pseudomonasand Neisseria showed significant differences (p<0.05) inpercentage of these species between groups I and II (Table 2). In Group I, the numbers of positive isolates of bacterialspecies were greater than that of the control group using traditional oral caremethods. For Veillonella and Actinomyces, nosignificant differences were shown between the two groups (Table 2).

Bottom Line: In this study, the oral cavity microorganisms such as bacteria and yeast were taken for the analysis.Here, we used antimicrobial agents which are common in clinical practice.The oxacillin resistance of S. aureus isolate confirms that the prevalence of MRSA is increasing in accordance to age-factor and immune compromise in elderly patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthodontics, Shanghai Stomatological Disease Centre, Shanghai, China.

ABSTRACT

Objective: The immune compromised patients after treatment of oral cancer may have a chance of infection by drug-resistant opportunistic microbes. We investigated the occurrence of opportunistic microorganisms in aged individuals receiving follow-up examinations after treatment of oral cancer in China.

Material and methods: These patients were used as test group and the respective age grouped healthy individuals as control group. In this study, the oral cavity microorganisms such as bacteria and yeast were taken for the analysis. After the screening of representative microorganisms, their aptitude of pervasiveness against drugs was studied. Here, we used antimicrobial agents which are common in clinical practice. We also performed studies to investigate the presence of toxin genes in methicillin-resistant S. aureus (MRSA).

Results: The results indicate that the prevalence of drug-resistant microbes was more pronounced in oral cancer patients after initial treatment above 70 years old. The oxacillin resistance of S. aureus isolate confirms that the prevalence of MRSA is increasing in accordance to age-factor and immune compromise in elderly patients.

Conclusions: This study reveals the occurrence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer in aged individuals. Special attention should be directed to MRSA during the treatment of oral cancer, and to realize the fact of immune compromise in elderly patients.

Show MeSH
Related in: MedlinePlus