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The relationship between dehydroepiandrosterone (DHEA), working memory and distraction--a behavioral and electrophysiological approach.

do Vale S, Selinger L, Martins JM, Gomes AC, Bicho M, do Carmo I, Escera C - PLoS ONE (2014)

Bottom Line: Under working memory load, a higher baseline cortisol/DHEA ratio was related to higher distraction as indexed by an enhanced novelty P3.An increased DHEA production with consecutive cognitive tasks was found and higher DHEA responses attributed to working memory load were related to enhanced working memory processing as indexed by an enhanced visual P300.Overall, the results suggest that in women DHEA may oppose cortisol effects reducing distraction and that a higher DHEA response may enhance working memory at the electrophysiological level.

View Article: PubMed Central - PubMed

Affiliation: Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Psychiatry and Clinical Psychobiology Department, University of Barcelona, Barcelona, Catalonia, Spain; Endocrinology University Clinic, Lisbon Medical School, University of Lisbon, Lisbon, Portugal; Endocrinology, Diabetes and Metabolism Department, Santa Maria University Hospital, Lisbon, Portugal; Metabolism and Endocrinology Center, Genetics Laboratory, Lisbon Medical School, University of Lisbon, Lisbon, Portugal.

ABSTRACT
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) have been reported to have memory enhancement effects in humans. A neuro-stimulatory action and an anti-cortisol mechanism of action may contribute to that relation. In order to study DHEA, DHEAS and cortisol relations to working memory and distraction, we recorded the electroencephalogram of 23 young women performing a discrimination (no working memory load) or 1-back (working memory load) task in an audio-visual oddball paradigm. We measured salivary DHEA, DHEAS and cortisol both before each task and at 30 and 60 min. Under working memory load, a higher baseline cortisol/DHEA ratio was related to higher distraction as indexed by an enhanced novelty P3. This suggests that cortisol may lead to increased distraction whereas DHEA may hinder distraction by leading to less processing of the distractor. An increased DHEA production with consecutive cognitive tasks was found and higher DHEA responses attributed to working memory load were related to enhanced working memory processing as indexed by an enhanced visual P300. Overall, the results suggest that in women DHEA may oppose cortisol effects reducing distraction and that a higher DHEA response may enhance working memory at the electrophysiological level.

Show MeSH
The visP300 amplitude changed between tasks (WM0, WM1) in direct relation to DHEA response.WM0 – discrimination task; WM1 – working memory task. Δ DHEA response = DHEA response in WM1 – DHEA response in WM0; Δ visP300 = mean visual P300 in WM1 - mean visual P300 in WM0.
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pone-0104869-g007: The visP300 amplitude changed between tasks (WM0, WM1) in direct relation to DHEA response.WM0 – discrimination task; WM1 – working memory task. Δ DHEA response = DHEA response in WM1 – DHEA response in WM0; Δ visP300 = mean visual P300 in WM1 - mean visual P300 in WM0.

Mentions: The results showed that visP300 change between tasks was directly related to Δ DHEA response as supported by a significant interaction between visP300 amplitude×Δ DHEA response [F(1,20) = 9.244, p = 0.006] and a direct relation between visP300 enhancement and DHEA response increase attributed to WM load (rs = 0.587, n = 22, p = 0.004; see Figure 7). The difference of visP300 latency between tasks was not related to the endocrine parameters.


The relationship between dehydroepiandrosterone (DHEA), working memory and distraction--a behavioral and electrophysiological approach.

do Vale S, Selinger L, Martins JM, Gomes AC, Bicho M, do Carmo I, Escera C - PLoS ONE (2014)

The visP300 amplitude changed between tasks (WM0, WM1) in direct relation to DHEA response.WM0 – discrimination task; WM1 – working memory task. Δ DHEA response = DHEA response in WM1 – DHEA response in WM0; Δ visP300 = mean visual P300 in WM1 - mean visual P300 in WM0.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126777&req=5

pone-0104869-g007: The visP300 amplitude changed between tasks (WM0, WM1) in direct relation to DHEA response.WM0 – discrimination task; WM1 – working memory task. Δ DHEA response = DHEA response in WM1 – DHEA response in WM0; Δ visP300 = mean visual P300 in WM1 - mean visual P300 in WM0.
Mentions: The results showed that visP300 change between tasks was directly related to Δ DHEA response as supported by a significant interaction between visP300 amplitude×Δ DHEA response [F(1,20) = 9.244, p = 0.006] and a direct relation between visP300 enhancement and DHEA response increase attributed to WM load (rs = 0.587, n = 22, p = 0.004; see Figure 7). The difference of visP300 latency between tasks was not related to the endocrine parameters.

Bottom Line: Under working memory load, a higher baseline cortisol/DHEA ratio was related to higher distraction as indexed by an enhanced novelty P3.An increased DHEA production with consecutive cognitive tasks was found and higher DHEA responses attributed to working memory load were related to enhanced working memory processing as indexed by an enhanced visual P300.Overall, the results suggest that in women DHEA may oppose cortisol effects reducing distraction and that a higher DHEA response may enhance working memory at the electrophysiological level.

View Article: PubMed Central - PubMed

Affiliation: Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Cognitive Neuroscience Research Group, Psychiatry and Clinical Psychobiology Department, University of Barcelona, Barcelona, Catalonia, Spain; Endocrinology University Clinic, Lisbon Medical School, University of Lisbon, Lisbon, Portugal; Endocrinology, Diabetes and Metabolism Department, Santa Maria University Hospital, Lisbon, Portugal; Metabolism and Endocrinology Center, Genetics Laboratory, Lisbon Medical School, University of Lisbon, Lisbon, Portugal.

ABSTRACT
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) have been reported to have memory enhancement effects in humans. A neuro-stimulatory action and an anti-cortisol mechanism of action may contribute to that relation. In order to study DHEA, DHEAS and cortisol relations to working memory and distraction, we recorded the electroencephalogram of 23 young women performing a discrimination (no working memory load) or 1-back (working memory load) task in an audio-visual oddball paradigm. We measured salivary DHEA, DHEAS and cortisol both before each task and at 30 and 60 min. Under working memory load, a higher baseline cortisol/DHEA ratio was related to higher distraction as indexed by an enhanced novelty P3. This suggests that cortisol may lead to increased distraction whereas DHEA may hinder distraction by leading to less processing of the distractor. An increased DHEA production with consecutive cognitive tasks was found and higher DHEA responses attributed to working memory load were related to enhanced working memory processing as indexed by an enhanced visual P300. Overall, the results suggest that in women DHEA may oppose cortisol effects reducing distraction and that a higher DHEA response may enhance working memory at the electrophysiological level.

Show MeSH