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Resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats.

Mota MM, Silva TL, Fontes MT, Barreto AS, Araújo JE, Oliveira AC, Wichi RB, Santos MR - Arq. Bras. Cardiol. (2014)

Bottom Line: A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency.In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group.However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.

ABSTRACT

Background: Resistance exercise effects on cardiovascular parameters are not consistent.

Objectives: The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats.

Methods: Wistar rats were divided into three groups: control group (n = 8); sedentary diabetic (n = 8); and trained diabetic (n = 8). Resistance exercise was carried out in a squat device for rats and consisted of three sets of ten repetitions with an intensity of 50%, three times per week, for eight weeks. Changes in vascular reactivity were evaluated in superior mesenteric artery rings.

Results: A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency. In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group. Furthermore, a significant increase (p < 0.05) in mean arterial blood pressure was observed in the sedentary diabetic group (104.9 ± 5 to 126.7 ± 5 mmHg) as compared to that in the control group. However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group.

Conclusions: Resistance exercise could restore endothelial function and prevent an increase in arterial blood pressure in type 1 diabetic rats.

Show MeSH
Correlation between blood glucose levels and the percentage of maximum responseof acetylcholine-induced relaxations in superior mesenteric artery rings of thegroups diabetic sedentary (A) and diabetic trained (B).
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f03: Correlation between blood glucose levels and the percentage of maximum responseof acetylcholine-induced relaxations in superior mesenteric artery rings of thegroups diabetic sedentary (A) and diabetic trained (B).

Mentions: Figure 2 shows ACh induced relaxation,depending on its concentration, in isolated rings of the superior mesenteric artery,with intact endothelium in all groups. Neither diabetes, nor resistance exerciseinterfered with arterial sensitivity, considering that the concentration from whichthe agonist produces 50% of maximum response (potency - pD2) remainedunaltered. However, in group DS, diabetes reduced (p < 0.001) the maximum response(Rmax) as compared to that in group C. That was reversed (p < 0.01) in DT animals.In addition, a strong negative correlation was observed between ACh-inducedrelaxation and blood glucose levels in groups DS (r = -0.9710; p = 0.001, n = 8) andDT (r = -0.9874; p = 0.001, n = 8) (Figure3).


Resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats.

Mota MM, Silva TL, Fontes MT, Barreto AS, Araújo JE, Oliveira AC, Wichi RB, Santos MR - Arq. Bras. Cardiol. (2014)

Correlation between blood glucose levels and the percentage of maximum responseof acetylcholine-induced relaxations in superior mesenteric artery rings of thegroups diabetic sedentary (A) and diabetic trained (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126758&req=5

f03: Correlation between blood glucose levels and the percentage of maximum responseof acetylcholine-induced relaxations in superior mesenteric artery rings of thegroups diabetic sedentary (A) and diabetic trained (B).
Mentions: Figure 2 shows ACh induced relaxation,depending on its concentration, in isolated rings of the superior mesenteric artery,with intact endothelium in all groups. Neither diabetes, nor resistance exerciseinterfered with arterial sensitivity, considering that the concentration from whichthe agonist produces 50% of maximum response (potency - pD2) remainedunaltered. However, in group DS, diabetes reduced (p < 0.001) the maximum response(Rmax) as compared to that in group C. That was reversed (p < 0.01) in DT animals.In addition, a strong negative correlation was observed between ACh-inducedrelaxation and blood glucose levels in groups DS (r = -0.9710; p = 0.001, n = 8) andDT (r = -0.9874; p = 0.001, n = 8) (Figure3).

Bottom Line: A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency.In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group.However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.

ABSTRACT

Background: Resistance exercise effects on cardiovascular parameters are not consistent.

Objectives: The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats.

Methods: Wistar rats were divided into three groups: control group (n = 8); sedentary diabetic (n = 8); and trained diabetic (n = 8). Resistance exercise was carried out in a squat device for rats and consisted of three sets of ten repetitions with an intensity of 50%, three times per week, for eight weeks. Changes in vascular reactivity were evaluated in superior mesenteric artery rings.

Results: A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency. In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group. Furthermore, a significant increase (p < 0.05) in mean arterial blood pressure was observed in the sedentary diabetic group (104.9 ± 5 to 126.7 ± 5 mmHg) as compared to that in the control group. However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group.

Conclusions: Resistance exercise could restore endothelial function and prevent an increase in arterial blood pressure in type 1 diabetic rats.

Show MeSH