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Effect of pitavastatin on vascular reactivity in hypercholesterolemic rabbits.

Almeida EA, Ozaki MR - Arq. Bras. Cardiol. (2014)

Bottom Line: HDL was significantly reduced in G4, G5 and G6 when compared to G2.Significantly endothelial dysfunction reversion was observed in G5 and G6 when compared to G2.Pitavastatin starting at a 0.5 mg dose was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.

View Article: PubMed Central - PubMed

Affiliation: Universidade Estadual de Campinas, Campinas, SP, Brazil.

ABSTRACT

Background: Pitavastatin is the newest statin available in Brazil and likely the one with fewer side effects. Thus, pitavastatin was evaluated in hypercholesterolemic rabbits in relation to its action on vascular reactivity.

Objective: To assess the lowest dose of pitavastatin necessary to reduce plasma lipids, cholesterol and tissue lipid peroxidation, as well as endothelial function in hypercholesterolemic rabbits.

Methods: Thirty rabbits divided into six groups (n = 5): G1 - standard chow diet; G2 - hypercholesterolemic diet for 30 days; G3 - hypercholesterolemic diet and after the 16th day, diet supplemented with pitavastatin (0.1 mg); G4 - hypercholesterolemic diet supplemented with pitavastatin (0.25 mg); G5 - hypercholesterolemic diet supplemented with pitavastatin (0.5 mg); G6 - hypercholesterolemic diet supplemented with pitavastatin (1.0 mg). After 30 days, total cholesterol, HDL, triglycerides, glucose, creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT) were measured and LDL was calculated. In-depth anesthesia was performed with sodium thiopental and aortic segments were removed to study endothelial function, cholesterol and tissue lipid peroxidation. The significance level for statistical tests was 5%.

Results: Total cholesterol and LDL were significantly elevated in relation to G1. HDL was significantly reduced in G4, G5 and G6 when compared to G2. Triglycerides, CK, AST, ALT, cholesterol and tissue lipid peroxidation showed no statistical difference between G2 and G3-G6. Significantly endothelial dysfunction reversion was observed in G5 and G6 when compared to G2.

Conclusion: Pitavastatin starting at a 0.5 mg dose was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.

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Related in: MedlinePlus

Triglycerides in all groups expressed as mean and standard deviation.
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f04: Triglycerides in all groups expressed as mean and standard deviation.

Mentions: Figure 4, depicting triglycerides, showed that adecrease occurred in G3 (44.62%), G4 (33.53%), G5 (52.05%) and G6 (45.56%), but with nostatistically significant difference when compared to G2.


Effect of pitavastatin on vascular reactivity in hypercholesterolemic rabbits.

Almeida EA, Ozaki MR - Arq. Bras. Cardiol. (2014)

Triglycerides in all groups expressed as mean and standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126755&req=5

f04: Triglycerides in all groups expressed as mean and standard deviation.
Mentions: Figure 4, depicting triglycerides, showed that adecrease occurred in G3 (44.62%), G4 (33.53%), G5 (52.05%) and G6 (45.56%), but with nostatistically significant difference when compared to G2.

Bottom Line: HDL was significantly reduced in G4, G5 and G6 when compared to G2.Significantly endothelial dysfunction reversion was observed in G5 and G6 when compared to G2.Pitavastatin starting at a 0.5 mg dose was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.

View Article: PubMed Central - PubMed

Affiliation: Universidade Estadual de Campinas, Campinas, SP, Brazil.

ABSTRACT

Background: Pitavastatin is the newest statin available in Brazil and likely the one with fewer side effects. Thus, pitavastatin was evaluated in hypercholesterolemic rabbits in relation to its action on vascular reactivity.

Objective: To assess the lowest dose of pitavastatin necessary to reduce plasma lipids, cholesterol and tissue lipid peroxidation, as well as endothelial function in hypercholesterolemic rabbits.

Methods: Thirty rabbits divided into six groups (n = 5): G1 - standard chow diet; G2 - hypercholesterolemic diet for 30 days; G3 - hypercholesterolemic diet and after the 16th day, diet supplemented with pitavastatin (0.1 mg); G4 - hypercholesterolemic diet supplemented with pitavastatin (0.25 mg); G5 - hypercholesterolemic diet supplemented with pitavastatin (0.5 mg); G6 - hypercholesterolemic diet supplemented with pitavastatin (1.0 mg). After 30 days, total cholesterol, HDL, triglycerides, glucose, creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT) were measured and LDL was calculated. In-depth anesthesia was performed with sodium thiopental and aortic segments were removed to study endothelial function, cholesterol and tissue lipid peroxidation. The significance level for statistical tests was 5%.

Results: Total cholesterol and LDL were significantly elevated in relation to G1. HDL was significantly reduced in G4, G5 and G6 when compared to G2. Triglycerides, CK, AST, ALT, cholesterol and tissue lipid peroxidation showed no statistical difference between G2 and G3-G6. Significantly endothelial dysfunction reversion was observed in G5 and G6 when compared to G2.

Conclusion: Pitavastatin starting at a 0.5 mg dose was effective in reverting endothelial dysfunction in hypercholesterolemic rabbits.

Show MeSH
Related in: MedlinePlus