Limits...
Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness.

Yang F, Wang G, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, Mao J, Shi Y, Yang T - PLoS ONE (2014)

Bottom Line: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022).Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01).However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

ABSTRACT

Objective: The relationship between obesity and cardiovascular disease (CVD) remains unclear. This study aims to describe the relationship between arterial stiffness and obesity in order to investigate the effects of obesity on CVD.

Methods: We collected data from 5,158 individuals over 40 years of age from a cross-sectional study in Nanjing, China. Anthropometric, demographic, hemodynamic measurements and arterial stiffness measured through brachial-ankle pulse wave velocity (baPWV) were obtained. Subjects were grouped by body mass index (BMI), waist circumference (WC) and visceral adiposity index (VAI), a sex-specific index based on BMI, WC, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C).

Results: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022). The unadjusted baPWV significantly increased across groups with higher obesity categories (P<0.01). Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01). No differences were observed among the metabolically healthy groups or the metabolically abnormal groups in the BMI and WC categories (P>0.05). However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

Conclusions: This study supports the concept of heterogeneity of metabolic status among individuals within the same obesity range. Obese individuals are at an increased risk of arterial stiffness regardless of their metabolic conditions. VAI may be a surrogate marker for the assessment of obesity and the effects of obesity on arterial stiffness.

Show MeSH

Related in: MedlinePlus

Association between body size phenotypes (combined consideration of BMI or waist circumference categories or visceral adiposity index quartiles and the absence or presence of the abnormal metabolic components) and brachial-ankle pulse wave velocity (mean ± s.e.) after adjustments for age and heart rate.MH, metabolically healthy individuals; MA, metabolically abnormal individuals; baPWV, brachial-ankle pulse wave velocity. * P<0.01 for the comparison to the metabolically abnormal first category; ** P<0.01 for the comparison to the metabolically healthy first category.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4126713&req=5

pone-0104365-g002: Association between body size phenotypes (combined consideration of BMI or waist circumference categories or visceral adiposity index quartiles and the absence or presence of the abnormal metabolic components) and brachial-ankle pulse wave velocity (mean ± s.e.) after adjustments for age and heart rate.MH, metabolically healthy individuals; MA, metabolically abnormal individuals; baPWV, brachial-ankle pulse wave velocity. * P<0.01 for the comparison to the metabolically abnormal first category; ** P<0.01 for the comparison to the metabolically healthy first category.

Mentions: In order to further assess the effect of obesity on arterial stiffness, body size phenotypes were defined based on the combined consideration of the absence or presence of the abnormal metabolic components and the obesity categories. Compared with the metabolically abnormal category, metabolically healthy individuals had a lower value of baPWV regardless of their obesity category (Fig 2a, b, c; P<0.01). Similarly, the metabolically abnormal individuals had an unfavorable value in baPWV compared to the metabolically healthy category (Fig 2a, b, c; P<0.01). No differences were observed among the metabolically healthy groups or the metabolically abnormal groups in the BMI and WC category (Fig 2a, b; P>0.05). However, baPWV significantly increased across groups with higher VAI categories in the same metabolic category (Fig 2c; P<0.01).


Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness.

Yang F, Wang G, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, Mao J, Shi Y, Yang T - PLoS ONE (2014)

Association between body size phenotypes (combined consideration of BMI or waist circumference categories or visceral adiposity index quartiles and the absence or presence of the abnormal metabolic components) and brachial-ankle pulse wave velocity (mean ± s.e.) after adjustments for age and heart rate.MH, metabolically healthy individuals; MA, metabolically abnormal individuals; baPWV, brachial-ankle pulse wave velocity. * P<0.01 for the comparison to the metabolically abnormal first category; ** P<0.01 for the comparison to the metabolically healthy first category.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126713&req=5

pone-0104365-g002: Association between body size phenotypes (combined consideration of BMI or waist circumference categories or visceral adiposity index quartiles and the absence or presence of the abnormal metabolic components) and brachial-ankle pulse wave velocity (mean ± s.e.) after adjustments for age and heart rate.MH, metabolically healthy individuals; MA, metabolically abnormal individuals; baPWV, brachial-ankle pulse wave velocity. * P<0.01 for the comparison to the metabolically abnormal first category; ** P<0.01 for the comparison to the metabolically healthy first category.
Mentions: In order to further assess the effect of obesity on arterial stiffness, body size phenotypes were defined based on the combined consideration of the absence or presence of the abnormal metabolic components and the obesity categories. Compared with the metabolically abnormal category, metabolically healthy individuals had a lower value of baPWV regardless of their obesity category (Fig 2a, b, c; P<0.01). Similarly, the metabolically abnormal individuals had an unfavorable value in baPWV compared to the metabolically healthy category (Fig 2a, b, c; P<0.01). No differences were observed among the metabolically healthy groups or the metabolically abnormal groups in the BMI and WC category (Fig 2a, b; P>0.05). However, baPWV significantly increased across groups with higher VAI categories in the same metabolic category (Fig 2c; P<0.01).

Bottom Line: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022).Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01).However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

ABSTRACT

Objective: The relationship between obesity and cardiovascular disease (CVD) remains unclear. This study aims to describe the relationship between arterial stiffness and obesity in order to investigate the effects of obesity on CVD.

Methods: We collected data from 5,158 individuals over 40 years of age from a cross-sectional study in Nanjing, China. Anthropometric, demographic, hemodynamic measurements and arterial stiffness measured through brachial-ankle pulse wave velocity (baPWV) were obtained. Subjects were grouped by body mass index (BMI), waist circumference (WC) and visceral adiposity index (VAI), a sex-specific index based on BMI, WC, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C).

Results: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022). The unadjusted baPWV significantly increased across groups with higher obesity categories (P<0.01). Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01). No differences were observed among the metabolically healthy groups or the metabolically abnormal groups in the BMI and WC categories (P>0.05). However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

Conclusions: This study supports the concept of heterogeneity of metabolic status among individuals within the same obesity range. Obese individuals are at an increased risk of arterial stiffness regardless of their metabolic conditions. VAI may be a surrogate marker for the assessment of obesity and the effects of obesity on arterial stiffness.

Show MeSH
Related in: MedlinePlus