Limits...
Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness.

Yang F, Wang G, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, Mao J, Shi Y, Yang T - PLoS ONE (2014)

Bottom Line: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022).Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01).However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

ABSTRACT

Objective: The relationship between obesity and cardiovascular disease (CVD) remains unclear. This study aims to describe the relationship between arterial stiffness and obesity in order to investigate the effects of obesity on CVD.

Methods: We collected data from 5,158 individuals over 40 years of age from a cross-sectional study in Nanjing, China. Anthropometric, demographic, hemodynamic measurements and arterial stiffness measured through brachial-ankle pulse wave velocity (baPWV) were obtained. Subjects were grouped by body mass index (BMI), waist circumference (WC) and visceral adiposity index (VAI), a sex-specific index based on BMI, WC, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C).

Results: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022). The unadjusted baPWV significantly increased across groups with higher obesity categories (P<0.01). Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01). No differences were observed among the metabolically healthy groups or the metabolically abnormal groups in the BMI and WC categories (P>0.05). However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

Conclusions: This study supports the concept of heterogeneity of metabolic status among individuals within the same obesity range. Obese individuals are at an increased risk of arterial stiffness regardless of their metabolic conditions. VAI may be a surrogate marker for the assessment of obesity and the effects of obesity on arterial stiffness.

Show MeSH

Related in: MedlinePlus

Relationship between obesity category (based on BMI, waist circumference and visceral adiposity index) and brachial-ankle pulse wave velocity (mean ± s.e.).a, b, c: Before adjustments. d, e: After adjustments for systolic blood pressure (SBP), age, heart rate, 120-min post-OGTT plasma glucose (PG120) and lipids. f: After adjustments for SBP, age, heart rate, PG120, low-density lipoprotein cholesterol and cholesterol. * P<0.01 for the comparison to the first category or first visceral adiposity index quartile.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4126713&req=5

pone-0104365-g001: Relationship between obesity category (based on BMI, waist circumference and visceral adiposity index) and brachial-ankle pulse wave velocity (mean ± s.e.).a, b, c: Before adjustments. d, e: After adjustments for systolic blood pressure (SBP), age, heart rate, 120-min post-OGTT plasma glucose (PG120) and lipids. f: After adjustments for SBP, age, heart rate, PG120, low-density lipoprotein cholesterol and cholesterol. * P<0.01 for the comparison to the first category or first visceral adiposity index quartile.

Mentions: The relationship between obesity category (based on BMI, WC and VAI) and baPWV is showed in Figure 1. The unadjusted baPWV significantly increased across groups with higher obesity categories (Fig 1a, b, c; P<0.01). After adjusting for SBP, age, HR, PG120 and lipids, the positive association disappeared in the BMI and WC categories (Fig 1d, e; P>0.05) but was still observed between baPWV and VAI quartile (Fig 1f; P<0.01).


Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness.

Yang F, Wang G, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, Mao J, Shi Y, Yang T - PLoS ONE (2014)

Relationship between obesity category (based on BMI, waist circumference and visceral adiposity index) and brachial-ankle pulse wave velocity (mean ± s.e.).a, b, c: Before adjustments. d, e: After adjustments for systolic blood pressure (SBP), age, heart rate, 120-min post-OGTT plasma glucose (PG120) and lipids. f: After adjustments for SBP, age, heart rate, PG120, low-density lipoprotein cholesterol and cholesterol. * P<0.01 for the comparison to the first category or first visceral adiposity index quartile.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126713&req=5

pone-0104365-g001: Relationship between obesity category (based on BMI, waist circumference and visceral adiposity index) and brachial-ankle pulse wave velocity (mean ± s.e.).a, b, c: Before adjustments. d, e: After adjustments for systolic blood pressure (SBP), age, heart rate, 120-min post-OGTT plasma glucose (PG120) and lipids. f: After adjustments for SBP, age, heart rate, PG120, low-density lipoprotein cholesterol and cholesterol. * P<0.01 for the comparison to the first category or first visceral adiposity index quartile.
Mentions: The relationship between obesity category (based on BMI, WC and VAI) and baPWV is showed in Figure 1. The unadjusted baPWV significantly increased across groups with higher obesity categories (Fig 1a, b, c; P<0.01). After adjusting for SBP, age, HR, PG120 and lipids, the positive association disappeared in the BMI and WC categories (Fig 1d, e; P>0.05) but was still observed between baPWV and VAI quartile (Fig 1f; P<0.01).

Bottom Line: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022).Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01).However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

ABSTRACT

Objective: The relationship between obesity and cardiovascular disease (CVD) remains unclear. This study aims to describe the relationship between arterial stiffness and obesity in order to investigate the effects of obesity on CVD.

Methods: We collected data from 5,158 individuals over 40 years of age from a cross-sectional study in Nanjing, China. Anthropometric, demographic, hemodynamic measurements and arterial stiffness measured through brachial-ankle pulse wave velocity (baPWV) were obtained. Subjects were grouped by body mass index (BMI), waist circumference (WC) and visceral adiposity index (VAI), a sex-specific index based on BMI, WC, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C).

Results: The multivariate regression analysis revealed a negative but weak effect of BMI (β = -0.047, P<0.001) on baPWV, but failed to demonstrate any significant effect of WC on baPWV while VAI was a positive independent indicator of baPWV (β = 0.023, P = 0.022). The unadjusted baPWV significantly increased across groups with higher obesity categories (P<0.01). Although the positive association was lost after adjustments for confounding factors in the BMI or WC categories (P>0.05), it was still obtained between baPWV and VAI quartile (P<0.01). No differences were observed among the metabolically healthy groups or the metabolically abnormal groups in the BMI and WC categories (P>0.05). However, baPWV significantly increased across groups with higher VAI categories even in the same metabolic category (P<0.01).

Conclusions: This study supports the concept of heterogeneity of metabolic status among individuals within the same obesity range. Obese individuals are at an increased risk of arterial stiffness regardless of their metabolic conditions. VAI may be a surrogate marker for the assessment of obesity and the effects of obesity on arterial stiffness.

Show MeSH
Related in: MedlinePlus