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Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication: a preliminary study.

Kim JH, Choi H, Sun HY, Doo SW, Yoon JH, Yang WJ, Yoo BW, Kim JM, Kwon SS, Song ES, Lee HJ, Lim IS, Song YS - BMC Urol (2014)

Bottom Line: Patients were divided into 2 groups according to BMI or WC.Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement.Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul Hospital, 59, Daesagwan-ro, Yongsan-gu, Seoul 140-743, The Republic of Korea. yssong@schmc.ac.kr.

ABSTRACT

Background: The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity.

Methods: An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed.

Results: Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1%) had BMI ≥ 23 kg/m2, and 24 (25.0%) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001).

Conclusions: Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality.

Trial registration: Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang University Hospital.

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Flow chart of enrolled patients.
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Figure 1: Flow chart of enrolled patients.

Mentions: Of the 140 enrolled patients, 96 completed the study. Fifty four patients discontinued the trial. Of these, 22 were lost to follow-up, 14 refused to complete the final questionnaires, and 18 patients discontinued the medication because of low efficacy (9 patients) or adverse events (9 patients) (Figure 1).


Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication: a preliminary study.

Kim JH, Choi H, Sun HY, Doo SW, Yoon JH, Yang WJ, Yoo BW, Kim JM, Kwon SS, Song ES, Lee HJ, Lim IS, Song YS - BMC Urol (2014)

Flow chart of enrolled patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4126641&req=5

Figure 1: Flow chart of enrolled patients.
Mentions: Of the 140 enrolled patients, 96 completed the study. Fifty four patients discontinued the trial. Of these, 22 were lost to follow-up, 14 refused to complete the final questionnaires, and 18 patients discontinued the medication because of low efficacy (9 patients) or adverse events (9 patients) (Figure 1).

Bottom Line: Patients were divided into 2 groups according to BMI or WC.Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement.Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul Hospital, 59, Daesagwan-ro, Yongsan-gu, Seoul 140-743, The Republic of Korea. yssong@schmc.ac.kr.

ABSTRACT

Background: The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity.

Methods: An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed.

Results: Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1%) had BMI ≥ 23 kg/m2, and 24 (25.0%) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001).

Conclusions: Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality.

Trial registration: Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang University Hospital.

Show MeSH
Related in: MedlinePlus