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Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer.

Wohlrab J, Bangemann N, Kleine-Tebbe A, Thill M, Kümmel S, Grischke EM, Richter R, Seite S, Lüftner D - Breast Cancer (Dove Med Press) (2014)

Bottom Line: However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation.Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

View Article: PubMed Central - PubMed

Affiliation: Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale), Germany.

ABSTRACT

Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3.

Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and irritability have been assessed using visual analog scales.

Results: Regarding the total score of the Dermatology Life Quality Index, no relevant differences could be observed. However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation. Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).

Conclusion: The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

No MeSH data available.


Related in: MedlinePlus

VAS: comparison of both groups over application time.Notes: (A) Pruritus, (B) skin dryness, (C) irritability. Standard care/test preparation group n=48; test preparation/standard care group n=46. *Statistical significant difference between the groups, analysis of variance (P≤0.05).Abbreviation: VAS, visual analog scale.
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f3-bctt-6-115: VAS: comparison of both groups over application time.Notes: (A) Pruritus, (B) skin dryness, (C) irritability. Standard care/test preparation group n=48; test preparation/standard care group n=46. *Statistical significant difference between the groups, analysis of variance (P≤0.05).Abbreviation: VAS, visual analog scale.

Mentions: Comparing the total DLQI score between TP and SC after 6 weeks did not show any significant differences (Figure 2A). However, the analysis of the six subscales showed significant superiority of TP for the “symptoms and feelings” aspect after week 4. After crossover, superiority of TP can be observed after week 8 (Figure 2B). For the other subscales, no significant differences could be found. The visual analog scale values for the secondary target parameters of pruritus, dryness, and irritability show significant superiority for TP after 6 weeks (Figure 3A–C).


Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer.

Wohlrab J, Bangemann N, Kleine-Tebbe A, Thill M, Kümmel S, Grischke EM, Richter R, Seite S, Lüftner D - Breast Cancer (Dove Med Press) (2014)

VAS: comparison of both groups over application time.Notes: (A) Pruritus, (B) skin dryness, (C) irritability. Standard care/test preparation group n=48; test preparation/standard care group n=46. *Statistical significant difference between the groups, analysis of variance (P≤0.05).Abbreviation: VAS, visual analog scale.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126578&req=5

f3-bctt-6-115: VAS: comparison of both groups over application time.Notes: (A) Pruritus, (B) skin dryness, (C) irritability. Standard care/test preparation group n=48; test preparation/standard care group n=46. *Statistical significant difference between the groups, analysis of variance (P≤0.05).Abbreviation: VAS, visual analog scale.
Mentions: Comparing the total DLQI score between TP and SC after 6 weeks did not show any significant differences (Figure 2A). However, the analysis of the six subscales showed significant superiority of TP for the “symptoms and feelings” aspect after week 4. After crossover, superiority of TP can be observed after week 8 (Figure 2B). For the other subscales, no significant differences could be found. The visual analog scale values for the secondary target parameters of pruritus, dryness, and irritability show significant superiority for TP after 6 weeks (Figure 3A–C).

Bottom Line: However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation.Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

View Article: PubMed Central - PubMed

Affiliation: Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale), Germany.

ABSTRACT

Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3.

Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and irritability have been assessed using visual analog scales.

Results: Regarding the total score of the Dermatology Life Quality Index, no relevant differences could be observed. However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation. Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).

Conclusion: The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

No MeSH data available.


Related in: MedlinePlus