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Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer.

Wohlrab J, Bangemann N, Kleine-Tebbe A, Thill M, Kümmel S, Grischke EM, Richter R, Seite S, Lüftner D - Breast Cancer (Dove Med Press) (2014)

Bottom Line: However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation.Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

View Article: PubMed Central - PubMed

Affiliation: Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale), Germany.

ABSTRACT

Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3.

Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and irritability have been assessed using visual analog scales.

Results: Regarding the total score of the Dermatology Life Quality Index, no relevant differences could be observed. However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation. Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).

Conclusion: The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

No MeSH data available.


Related in: MedlinePlus

CONSORT diagram.Abbreviations: SC, standard care; SC/TP, patient group that starts with SC followed by TP; TP, test preparation; TP/SC, patient group that starts with TP followed by SC; CONSORT, Consolidated Standards of Reporting Trials.
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f1-bctt-6-115: CONSORT diagram.Abbreviations: SC, standard care; SC/TP, patient group that starts with SC followed by TP; TP, test preparation; TP/SC, patient group that starts with TP followed by SC; CONSORT, Consolidated Standards of Reporting Trials.

Mentions: The study was conducted between February 2012 and April 2013 in six breast cancer centers in Germany. A total of 95 patients aged between 25 and 77 years were enrolled (Figure 1). Via block randomization, 46 patients were randomized in group TP/SC and 48 in group SC/TP. Twenty-one patients dropped out before the end of the study and one patient had to be excluded for protocol deviation. A total of 73 patients were included in the analysis.


Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer.

Wohlrab J, Bangemann N, Kleine-Tebbe A, Thill M, Kümmel S, Grischke EM, Richter R, Seite S, Lüftner D - Breast Cancer (Dove Med Press) (2014)

CONSORT diagram.Abbreviations: SC, standard care; SC/TP, patient group that starts with SC followed by TP; TP, test preparation; TP/SC, patient group that starts with TP followed by SC; CONSORT, Consolidated Standards of Reporting Trials.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126578&req=5

f1-bctt-6-115: CONSORT diagram.Abbreviations: SC, standard care; SC/TP, patient group that starts with SC followed by TP; TP, test preparation; TP/SC, patient group that starts with TP followed by SC; CONSORT, Consolidated Standards of Reporting Trials.
Mentions: The study was conducted between February 2012 and April 2013 in six breast cancer centers in Germany. A total of 95 patients aged between 25 and 77 years were enrolled (Figure 1). Via block randomization, 46 patients were randomized in group TP/SC and 48 in group SC/TP. Twenty-one patients dropped out before the end of the study and one patient had to be excluded for protocol deviation. A total of 73 patients were included in the analysis.

Bottom Line: However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation.Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

View Article: PubMed Central - PubMed

Affiliation: Martin Luther University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Saale), Germany.

ABSTRACT

Purpose: Chemotherapy with anthracyclines, taxanes, or alkylating agents often causes cutaneous side effects. Nonspecific inhibition of the proliferative activity of keratinocytes has antidifferentiation effects that lead to defects in the barrier function and, thus, to dry, itchy, and irritable skin. These cutaneous symptoms reduce the quality of life of the patients considerably. Conditioning with topical application of niacinamide uses the cytoprotective and barrier stabilizing effect of vitamin B3.

Patients and methods: A multicenter randomized crossover study investigated the influence of the test preparation on the quality of life compared to standard care for 73 patients with breast cancer undergoing adjuvant or neoadjuvant cytostatic therapy. Primary target parameter was the Dermatology Life Quality Index with its respective subscales after 6 weeks of a twice-daily application of the respective preparations. Additionally, specific symptoms such as pruritus, dryness, and irritability have been assessed using visual analog scales.

Results: Regarding the total score of the Dermatology Life Quality Index, no relevant differences could be observed. However, the results for the "symptoms and feelings" subscale show a significant advantage in favor of the test preparation. Significant superiority of the test preparation could also be observed in the secondary target parameters, the visual analog scales (P<0.05).

Conclusion: The results show for the first time a significant superiority of prophylactic application of niacinamide for maintaining quality of life while undergoing cytostatic treatment.

No MeSH data available.


Related in: MedlinePlus