Limits...
Management of neonatal sepsis in term newborns.

Du Pont-Thibodeau G, Joyal JS, Lacroix J - F1000Prime Rep (2014)

Bottom Line: It is broadly defined as a systemic inflammatory response, occurring in the first four weeks of life, as a result of a suspected or proven infection.Several therapeutic attempts to control systemic inflammation in sepsis were unsuccessful.Immediate empirical administration of broad-spectrum anti-microbials, aggressive fluid resuscitation, and vaso-active or inotropic support (or both) are the mainstays of the therapeutic management of neonatal sepsis.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics, Université de Montréal and Sainte-Justine Hospital 3175 Cote Sainte-Catherine, Montreal Canada H3T1C5.

ABSTRACT
Neonatal sepsis is a common and deadly disease. It is broadly defined as a systemic inflammatory response, occurring in the first four weeks of life, as a result of a suspected or proven infection. Yet, more reliable and consistently applied diagnostic criteria would help improve our knowledge of the disease epidemiology. Several therapeutic attempts to control systemic inflammation in sepsis were unsuccessful. Immediate empirical administration of broad-spectrum anti-microbials, aggressive fluid resuscitation, and vaso-active or inotropic support (or both) are the mainstays of the therapeutic management of neonatal sepsis.

No MeSH data available.


Related in: MedlinePlus

Relationship between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS).Upper panel: relationship according to infectious etiology. Lower panel: Venn diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4126544&req=5

fig-001: Relationship between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS).Upper panel: relationship according to infectious etiology. Lower panel: Venn diagram.

Mentions: Experts in critical care medicine defined three septic states: sepsis, severe sepsis, and septic shock [2,6]. Does it make sense? Leclerc et al. showed that there is an added prognostic value if one differentiates these three septic states: the hazard ratios of mortality were 7.43 (95% CI 1.01 to 54.8) in critically ill children with sepsis, 27.40 (95% CI 3.26 to 230.4) in patients who contracted severe sepsis, and 61.40 (95% CI 7.8 to 486.1) in those with septic shock [7]. Clearly, the frequency of these three septic states must be taken into account in all randomized controlled trials (RCTs) where the efficacy of a treatment is studied in critically ill children, including neonates. The relationship between SIRS, sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) is illustrated in Figure 1.


Management of neonatal sepsis in term newborns.

Du Pont-Thibodeau G, Joyal JS, Lacroix J - F1000Prime Rep (2014)

Relationship between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS).Upper panel: relationship according to infectious etiology. Lower panel: Venn diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126544&req=5

fig-001: Relationship between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS).Upper panel: relationship according to infectious etiology. Lower panel: Venn diagram.
Mentions: Experts in critical care medicine defined three septic states: sepsis, severe sepsis, and septic shock [2,6]. Does it make sense? Leclerc et al. showed that there is an added prognostic value if one differentiates these three septic states: the hazard ratios of mortality were 7.43 (95% CI 1.01 to 54.8) in critically ill children with sepsis, 27.40 (95% CI 3.26 to 230.4) in patients who contracted severe sepsis, and 61.40 (95% CI 7.8 to 486.1) in those with septic shock [7]. Clearly, the frequency of these three septic states must be taken into account in all randomized controlled trials (RCTs) where the efficacy of a treatment is studied in critically ill children, including neonates. The relationship between SIRS, sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) is illustrated in Figure 1.

Bottom Line: It is broadly defined as a systemic inflammatory response, occurring in the first four weeks of life, as a result of a suspected or proven infection.Several therapeutic attempts to control systemic inflammation in sepsis were unsuccessful.Immediate empirical administration of broad-spectrum anti-microbials, aggressive fluid resuscitation, and vaso-active or inotropic support (or both) are the mainstays of the therapeutic management of neonatal sepsis.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics, Université de Montréal and Sainte-Justine Hospital 3175 Cote Sainte-Catherine, Montreal Canada H3T1C5.

ABSTRACT
Neonatal sepsis is a common and deadly disease. It is broadly defined as a systemic inflammatory response, occurring in the first four weeks of life, as a result of a suspected or proven infection. Yet, more reliable and consistently applied diagnostic criteria would help improve our knowledge of the disease epidemiology. Several therapeutic attempts to control systemic inflammation in sepsis were unsuccessful. Immediate empirical administration of broad-spectrum anti-microbials, aggressive fluid resuscitation, and vaso-active or inotropic support (or both) are the mainstays of the therapeutic management of neonatal sepsis.

No MeSH data available.


Related in: MedlinePlus