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Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia

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Schematic of a thalamocortical module. The blue and red lines indicate excitatory and inhibitory connections, respectively. The solid lines represent connections associated with the same delay and the dotted lines denote connections without delay.
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Figure 1: Schematic of a thalamocortical module. The blue and red lines indicate excitatory and inhibitory connections, respectively. The solid lines represent connections associated with the same delay and the dotted lines denote connections without delay.

Mentions: The present work aims to reproduce certain changes observed experimentally in the EEG power spectrum over the frontal head region during general anesthesia induced by propofol. These observations include increased delta (0-4 Hz) and alpha (8-12 Hz) activities [1]. We extend a previous cortical model [2] and study a neuronal population model of a single thalamo-cortical module consisting of three different populations of neurons, namely cortical excitatory neurons, thalamocortical relay neurons and inhibitory thalamic reticular neurons (Fig. 1). Each module obeys a neural mass model. The cortical inhibitory population is neglected in our model to reveal the effect of propofol action in the thalamus. Our model describes well the characteristic spectral changes observed experimentally within the delta- and alpha- frequency bands in frontal and occipital electrodes with increasing concentration of propofol.


Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia
Schematic of a thalamocortical module. The blue and red lines indicate excitatory and inhibitory connections, respectively. The solid lines represent connections associated with the same delay and the dotted lines denote connections without delay.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4126420&req=5

Figure 1: Schematic of a thalamocortical module. The blue and red lines indicate excitatory and inhibitory connections, respectively. The solid lines represent connections associated with the same delay and the dotted lines denote connections without delay.
Mentions: The present work aims to reproduce certain changes observed experimentally in the EEG power spectrum over the frontal head region during general anesthesia induced by propofol. These observations include increased delta (0-4 Hz) and alpha (8-12 Hz) activities [1]. We extend a previous cortical model [2] and study a neuronal population model of a single thalamo-cortical module consisting of three different populations of neurons, namely cortical excitatory neurons, thalamocortical relay neurons and inhibitory thalamic reticular neurons (Fig. 1). Each module obeys a neural mass model. The cortical inhibitory population is neglected in our model to reveal the effect of propofol action in the thalamus. Our model describes well the characteristic spectral changes observed experimentally within the delta- and alpha- frequency bands in frontal and occipital electrodes with increasing concentration of propofol.

View Article: PubMed Central - HTML

No MeSH data available.