Limits...
Chronic upper airway obstruction induces abnormal sleep/wake dynamics in juvenile rats

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Traditional scoring of sleep provides little information about the process of transitioning between vigilance-states... The number of microarousals and trajectories from light SWS to wake and vice versa increased in the UAO group... Ritanserin consolidated sleep in both groups by decreasing the number of microarousals and trajectories between wake to light SWS, and increasing deep SWS in UAO... Traditional sleep scoring in 10-second epochs reveals little information about the process of transitioning between states, as cortical activity and behavior can change quite rapidly in rodents; the SST analysis provides second-by-second resolutions... Also, conventional scoring simply identifies discrete states, so it can overlook important variations within states, such as the distinctions between light and deep SWS or between sleep and wake states... We present evidence that SST enables visualization of vigilance-state transitions and velocities that were not evident by traditional scoring methods... These observations provide new insight on abnormal sleep and highlight the usefulness of SST in understanding the role of UAO on sleep dynamics.

No MeSH data available.


Spontaneous sleep in rats. Values of wake (W), light slow wave sleep (LSWS), deep slow wave sleep (DSWS) and paradoxical sleep (PS) are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4126418&req=5

Figure 1: Spontaneous sleep in rats. Values of wake (W), light slow wave sleep (LSWS), deep slow wave sleep (DSWS) and paradoxical sleep (PS) are shown.

Mentions: Using an approach similar to previous reports [1,2] defined a 2-dimensional (2D) state space technique (SST) using 2 spectral amplitude ratios calculated by dividing integrated spectral amplitudes at selected frequency bands. We calculated two spectral amplitude ratios by integrating the spectral amplitude over specific frequencies: 0.5-20/0.5-40 Hz for ratio 1 and 0.5-4/0.5-9 Hz for ratio 2. Each second of this ratio was mapped into the 2D state space, ratio 2 vs. ratio 1 (Figure 1). State space analysis yields wake at low ratio 1 values and SWS at high ratio 1 values. We used the SST to explore whether the abnormal sleep in UAO reflects sleep instability, faster movements, and abnormal transitions between vigilance-states.


Chronic upper airway obstruction induces abnormal sleep/wake dynamics in juvenile rats
Spontaneous sleep in rats. Values of wake (W), light slow wave sleep (LSWS), deep slow wave sleep (DSWS) and paradoxical sleep (PS) are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4126418&req=5

Figure 1: Spontaneous sleep in rats. Values of wake (W), light slow wave sleep (LSWS), deep slow wave sleep (DSWS) and paradoxical sleep (PS) are shown.
Mentions: Using an approach similar to previous reports [1,2] defined a 2-dimensional (2D) state space technique (SST) using 2 spectral amplitude ratios calculated by dividing integrated spectral amplitudes at selected frequency bands. We calculated two spectral amplitude ratios by integrating the spectral amplitude over specific frequencies: 0.5-20/0.5-40 Hz for ratio 1 and 0.5-4/0.5-9 Hz for ratio 2. Each second of this ratio was mapped into the 2D state space, ratio 2 vs. ratio 1 (Figure 1). State space analysis yields wake at low ratio 1 values and SWS at high ratio 1 values. We used the SST to explore whether the abnormal sleep in UAO reflects sleep instability, faster movements, and abnormal transitions between vigilance-states.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Traditional scoring of sleep provides little information about the process of transitioning between vigilance-states... The number of microarousals and trajectories from light SWS to wake and vice versa increased in the UAO group... Ritanserin consolidated sleep in both groups by decreasing the number of microarousals and trajectories between wake to light SWS, and increasing deep SWS in UAO... Traditional sleep scoring in 10-second epochs reveals little information about the process of transitioning between states, as cortical activity and behavior can change quite rapidly in rodents; the SST analysis provides second-by-second resolutions... Also, conventional scoring simply identifies discrete states, so it can overlook important variations within states, such as the distinctions between light and deep SWS or between sleep and wake states... We present evidence that SST enables visualization of vigilance-state transitions and velocities that were not evident by traditional scoring methods... These observations provide new insight on abnormal sleep and highlight the usefulness of SST in understanding the role of UAO on sleep dynamics.

No MeSH data available.