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Mentions: We utilize 878 recordings from embryonic rat cortex cell cultures collected from 60-electrode, grid-type (200 μm) MEA’s. We modeled each recording as a 60-node directed weighted graph with weights describing electrode connectivity and nodal clustering coefficients  as features. Principal components analysis (PCA) reduced the dimensionality of this feature space . We observe a dense core of recordings showing weak spike activity, and 3 classes defined by batch (labeled in Figure 1A). Surprised at this structure, we sought a non-biological explanation. We identified 13 defective or biased electrodes as sources of systematic measurement error. Removing the affected electrodes produced a more complex interplay of inter- and intra-batch variability (Figure 1B).
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