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Cellular mechanisms generating bursting activity in neuronal networks

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The burst duration (BD) and interburst interval (IBI) increase as the inverse of the square root of the difference between the corresponding parameter and its bifurcation value... The cornerstone bifurcation also determines the stereotypical transient responses of silent and spiking neurons... The mechanisms presented here are based on these transient responses... The first mechanism described half-center oscillator consisting of two intrinsically silent, mutually inhibitory neurons (Figure 1AB)... We found that if the half-activation voltage of a non-inactivating potassium current (V1/2,mk2) was systematically shifted towards the bifurcation value for the saddle-node bifurcation of periodic orbits, the BDs of both neurons increased in accordance with the inverse-square-root law and exhibited linear dependence on the spike number per burst... The second mechanism described the bursting activity of two intrinsically spiking, mutually excitatory neurons... The parameters of the neurons were in vicinity of the cornerstone bifurcation... This network exhibited synchronized bursting (Figure 1CD)... When the half-activation voltage of hyperpolarization-activated current (V1/2,mh) was systematically shifted to the bifurcation value, IBIs of both neurons increased in accordance with the inverse-square-root law and the BDs and the number of spikes per burst stayed constant (6 spikes per burst)... This study reveals new mechanisms controlling bursting activity in small neuronal networks based on cellular properties determining transient responses of endogenously spiking and silent neurons... These mechanisms are generic and could govern the bursting regimes in rhythmic neuronal network such as central pattern generators.

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The cornerstone bifurcation generates mechanisms controlling bursting in neural networks. (A). Two endogenously silent, mutually inhibitory coupled neurons produce alternating bursting activity. V1/2,mk2 controls BDs. (B). The BDs are depicted as blue dots. The curve fit for BDs took the form b/. (C). Two endogenously spiking, mutually inhibitory coupled neurons produce synchronous bursting activity. V1/2,mh controls IBIs. (D).Curve fit for IBIs took the form b/. The curves fitted to these data are depicted in red.
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Figure 1: The cornerstone bifurcation generates mechanisms controlling bursting in neural networks. (A). Two endogenously silent, mutually inhibitory coupled neurons produce alternating bursting activity. V1/2,mk2 controls BDs. (B). The BDs are depicted as blue dots. The curve fit for BDs took the form b/. (C). Two endogenously spiking, mutually inhibitory coupled neurons produce synchronous bursting activity. V1/2,mh controls IBIs. (D).Curve fit for IBIs took the form b/. The curves fitted to these data are depicted in red.

Mentions: The first mechanism described half-center oscillator consisting of two intrinsically silent, mutually inhibitory neurons (Figure 1AB). These two neurons were in the silent parameter regime but close to the cornerstone bifurcation. The two coupled neurons showed anti-phase bursting activity without the release and escape mechanisms. We found that if the half-activation voltage of a non-inactivating potassium current (V1/2,mk2) was systematically shifted towards the bifurcation value for the saddle-node bifurcation of periodic orbits, the BDs of both neurons increased in accordance with the inverse-square-root law and exhibited linear dependence on the spike number per burst.


Cellular mechanisms generating bursting activity in neuronal networks
The cornerstone bifurcation generates mechanisms controlling bursting in neural networks. (A). Two endogenously silent, mutually inhibitory coupled neurons produce alternating bursting activity. V1/2,mk2 controls BDs. (B). The BDs are depicted as blue dots. The curve fit for BDs took the form b/. (C). Two endogenously spiking, mutually inhibitory coupled neurons produce synchronous bursting activity. V1/2,mh controls IBIs. (D).Curve fit for IBIs took the form b/. The curves fitted to these data are depicted in red.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4126361&req=5

Figure 1: The cornerstone bifurcation generates mechanisms controlling bursting in neural networks. (A). Two endogenously silent, mutually inhibitory coupled neurons produce alternating bursting activity. V1/2,mk2 controls BDs. (B). The BDs are depicted as blue dots. The curve fit for BDs took the form b/. (C). Two endogenously spiking, mutually inhibitory coupled neurons produce synchronous bursting activity. V1/2,mh controls IBIs. (D).Curve fit for IBIs took the form b/. The curves fitted to these data are depicted in red.
Mentions: The first mechanism described half-center oscillator consisting of two intrinsically silent, mutually inhibitory neurons (Figure 1AB). These two neurons were in the silent parameter regime but close to the cornerstone bifurcation. The two coupled neurons showed anti-phase bursting activity without the release and escape mechanisms. We found that if the half-activation voltage of a non-inactivating potassium current (V1/2,mk2) was systematically shifted towards the bifurcation value for the saddle-node bifurcation of periodic orbits, the BDs of both neurons increased in accordance with the inverse-square-root law and exhibited linear dependence on the spike number per burst.

View Article: PubMed Central - HTML

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Please rate it.

The burst duration (BD) and interburst interval (IBI) increase as the inverse of the square root of the difference between the corresponding parameter and its bifurcation value... The cornerstone bifurcation also determines the stereotypical transient responses of silent and spiking neurons... The mechanisms presented here are based on these transient responses... The first mechanism described half-center oscillator consisting of two intrinsically silent, mutually inhibitory neurons (Figure 1AB)... We found that if the half-activation voltage of a non-inactivating potassium current (V1/2,mk2) was systematically shifted towards the bifurcation value for the saddle-node bifurcation of periodic orbits, the BDs of both neurons increased in accordance with the inverse-square-root law and exhibited linear dependence on the spike number per burst... The second mechanism described the bursting activity of two intrinsically spiking, mutually excitatory neurons... The parameters of the neurons were in vicinity of the cornerstone bifurcation... This network exhibited synchronized bursting (Figure 1CD)... When the half-activation voltage of hyperpolarization-activated current (V1/2,mh) was systematically shifted to the bifurcation value, IBIs of both neurons increased in accordance with the inverse-square-root law and the BDs and the number of spikes per burst stayed constant (6 spikes per burst)... This study reveals new mechanisms controlling bursting activity in small neuronal networks based on cellular properties determining transient responses of endogenously spiking and silent neurons... These mechanisms are generic and could govern the bursting regimes in rhythmic neuronal network such as central pattern generators.

No MeSH data available.