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Role of MR spectroscopy in musculoskeletal imaging.

Deshmukh S, Subhawong T, Carrino JA, Fayad L - Indian J Radiol Imaging (2014)

Bottom Line: By detecting signals of water, lipids, and other metabolites, MRS can provide metabolic information for lesion characterization and assessment of treatment response.Although MRS has been routinely used in the brain, clinical applications within the musculoskeletal system have only more recently emerged.The aim of this article is to review the technical considerations for performing MRS in the musculoskeletal system, focusing on proton MRS, and to discuss its potential roles in musculoskeletal tumor imaging and the assessment of muscle physiology and disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, Maryland, USA.

ABSTRACT
Magnetic resonance spectroscopy (MRS) is an imaging approach that allows for the noninvasive molecular characterization of a region of interest. By detecting signals of water, lipids, and other metabolites, MRS can provide metabolic information for lesion characterization and assessment of treatment response. Although MRS has been routinely used in the brain, clinical applications within the musculoskeletal system have only more recently emerged. The aim of this article is to review the technical considerations for performing MRS in the musculoskeletal system, focusing on proton MRS, and to discuss its potential roles in musculoskeletal tumor imaging and the assessment of muscle physiology and disease.

No MeSH data available.


Related in: MedlinePlus

A 31 year old male with high-grade osteosarcoma of the right thigh. Axial short TI inversion recovery (STIR) fast spin-echo MRI image (A), coronal T1-weighted spin-echo MRI image (B), and coronal fat-saturated dynamic contrast-enhanced fast spin-echo MRI image acquired 40 s after contrast injection (C) demonstrate a heterogeneous enhancing mass in the anterolateral right thigh with central areas of necrosis and surrounding edema. A single-voxel MR spectroscopic map (D) demonstrates a discrete choline peak at 3.2 ppm. (Reprinted with permission from AJR)[5]
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Figure 2: A 31 year old male with high-grade osteosarcoma of the right thigh. Axial short TI inversion recovery (STIR) fast spin-echo MRI image (A), coronal T1-weighted spin-echo MRI image (B), and coronal fat-saturated dynamic contrast-enhanced fast spin-echo MRI image acquired 40 s after contrast injection (C) demonstrate a heterogeneous enhancing mass in the anterolateral right thigh with central areas of necrosis and surrounding edema. A single-voxel MR spectroscopic map (D) demonstrates a discrete choline peak at 3.2 ppm. (Reprinted with permission from AJR)[5]

Mentions: Proton MRS detects signals of metabolites within a specified region of interest and provides metabolic information that can be used to evaluate suspected tumors. Since certain metabolites are distinctively increased in malignant lesions, MRS has the potential to noninvasively differentiate between malignant and benign lesions.[12512] In particular, the presence of elevated levels of the total choline (Cho) peak (trimethylamine/choline-containing compounds including phosphocholine, glycerophosphocholine, and free choline) has been established as a marker of malignancy. Choline-containing compounds are a part of the phosopholipid metabolism of cell membranes; hence, the level of choline within a region of interest will mirror the degree of cell membrane turnover that is known to occur in malignancy due to specific tumor growth factors.[1214] It follows that applications of choline measurement by MRS include the noninvasive characterization of newly detected masses [Figures 2 and 3] and the evaluation of treatment response.[12]


Role of MR spectroscopy in musculoskeletal imaging.

Deshmukh S, Subhawong T, Carrino JA, Fayad L - Indian J Radiol Imaging (2014)

A 31 year old male with high-grade osteosarcoma of the right thigh. Axial short TI inversion recovery (STIR) fast spin-echo MRI image (A), coronal T1-weighted spin-echo MRI image (B), and coronal fat-saturated dynamic contrast-enhanced fast spin-echo MRI image acquired 40 s after contrast injection (C) demonstrate a heterogeneous enhancing mass in the anterolateral right thigh with central areas of necrosis and surrounding edema. A single-voxel MR spectroscopic map (D) demonstrates a discrete choline peak at 3.2 ppm. (Reprinted with permission from AJR)[5]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126135&req=5

Figure 2: A 31 year old male with high-grade osteosarcoma of the right thigh. Axial short TI inversion recovery (STIR) fast spin-echo MRI image (A), coronal T1-weighted spin-echo MRI image (B), and coronal fat-saturated dynamic contrast-enhanced fast spin-echo MRI image acquired 40 s after contrast injection (C) demonstrate a heterogeneous enhancing mass in the anterolateral right thigh with central areas of necrosis and surrounding edema. A single-voxel MR spectroscopic map (D) demonstrates a discrete choline peak at 3.2 ppm. (Reprinted with permission from AJR)[5]
Mentions: Proton MRS detects signals of metabolites within a specified region of interest and provides metabolic information that can be used to evaluate suspected tumors. Since certain metabolites are distinctively increased in malignant lesions, MRS has the potential to noninvasively differentiate between malignant and benign lesions.[12512] In particular, the presence of elevated levels of the total choline (Cho) peak (trimethylamine/choline-containing compounds including phosphocholine, glycerophosphocholine, and free choline) has been established as a marker of malignancy. Choline-containing compounds are a part of the phosopholipid metabolism of cell membranes; hence, the level of choline within a region of interest will mirror the degree of cell membrane turnover that is known to occur in malignancy due to specific tumor growth factors.[1214] It follows that applications of choline measurement by MRS include the noninvasive characterization of newly detected masses [Figures 2 and 3] and the evaluation of treatment response.[12]

Bottom Line: By detecting signals of water, lipids, and other metabolites, MRS can provide metabolic information for lesion characterization and assessment of treatment response.Although MRS has been routinely used in the brain, clinical applications within the musculoskeletal system have only more recently emerged.The aim of this article is to review the technical considerations for performing MRS in the musculoskeletal system, focusing on proton MRS, and to discuss its potential roles in musculoskeletal tumor imaging and the assessment of muscle physiology and disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, Maryland, USA.

ABSTRACT
Magnetic resonance spectroscopy (MRS) is an imaging approach that allows for the noninvasive molecular characterization of a region of interest. By detecting signals of water, lipids, and other metabolites, MRS can provide metabolic information for lesion characterization and assessment of treatment response. Although MRS has been routinely used in the brain, clinical applications within the musculoskeletal system have only more recently emerged. The aim of this article is to review the technical considerations for performing MRS in the musculoskeletal system, focusing on proton MRS, and to discuss its potential roles in musculoskeletal tumor imaging and the assessment of muscle physiology and disease.

No MeSH data available.


Related in: MedlinePlus