Limits...
Acute Flaccid paralysis in adults: Our experience.

Kaushik R, Kharbanda PS, Bhalla A, Rajan R, Prabhakar S - J Emerg Trauma Shock (2014)

Bottom Line: Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions.We did not encounter any case of acute polio mylitis in adults.In-hospital mortality due to respiratory paralysis was 9%.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.

ABSTRACT

Unlabelled: Acute flaccid paralysis (AFP) is a complex clinical syndrome with a broad array of potential etiologies that vary with age. We present our experience of acute onset lower motor neuron paralysis.

Materials and methods: One hundred and thirty-three consecutive adult patients presenting with weakness of duration less than four weeks over 12 months period were enrolled. Detailed history, clinical examination, and relevant investigations according to a pre-defined diagnostic algorithm were carried out. The patients were followed through their hospital stay till discharge or death.

Results: The mean age was 33.27 (range 13-89) years with male preponderance (67.7%). The most common etiology was neuroparalytic snake envenomation (51.9%), followed by Guillain Barre syndrome (33.1%), constituting 85% of all patients. Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions. We did not encounter any case of acute polio mylitis in adults. In-hospital mortality due to respiratory paralysis was 9%.

Conclusion: Neuroparalytic snakebite and Guillain Barre syndrome were the most common causes of acute flaccid paralysis in adults in our study.

No MeSH data available.


Related in: MedlinePlus

Outcomes according to etiologies in patients with acute flaccid paralysis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4126112&req=5

Figure 4: Outcomes according to etiologies in patients with acute flaccid paralysis

Mentions: The median duration of hospital stay for all etiologies of acute flaccid paralysis was 6.00 days (25th percentile-4 days, 75th percentile-12 days). Mechanical ventilatory support was required in 66.2% cases. The median duration of ventilatory support was 4.00 days (25th percentile-3 days, 75th percentile-8.25 days). In the entire population, 63.2% completely recovered at discharge, 18% improved but had residual deficits at discharge, 9% died, 7% left against medical advice, and 4 cases (3%) had no improvement in muscle power at the time of discharge. A statistically significant difference was noted in outcomes among the various etiologies (P = 0.000). While 88.4% of the snake envenomations had complete recovery at discharge, only 25.0% of the LGBS group had a similar outcome [Figure 4].


Acute Flaccid paralysis in adults: Our experience.

Kaushik R, Kharbanda PS, Bhalla A, Rajan R, Prabhakar S - J Emerg Trauma Shock (2014)

Outcomes according to etiologies in patients with acute flaccid paralysis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126112&req=5

Figure 4: Outcomes according to etiologies in patients with acute flaccid paralysis
Mentions: The median duration of hospital stay for all etiologies of acute flaccid paralysis was 6.00 days (25th percentile-4 days, 75th percentile-12 days). Mechanical ventilatory support was required in 66.2% cases. The median duration of ventilatory support was 4.00 days (25th percentile-3 days, 75th percentile-8.25 days). In the entire population, 63.2% completely recovered at discharge, 18% improved but had residual deficits at discharge, 9% died, 7% left against medical advice, and 4 cases (3%) had no improvement in muscle power at the time of discharge. A statistically significant difference was noted in outcomes among the various etiologies (P = 0.000). While 88.4% of the snake envenomations had complete recovery at discharge, only 25.0% of the LGBS group had a similar outcome [Figure 4].

Bottom Line: Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions.We did not encounter any case of acute polio mylitis in adults.In-hospital mortality due to respiratory paralysis was 9%.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.

ABSTRACT

Unlabelled: Acute flaccid paralysis (AFP) is a complex clinical syndrome with a broad array of potential etiologies that vary with age. We present our experience of acute onset lower motor neuron paralysis.

Materials and methods: One hundred and thirty-three consecutive adult patients presenting with weakness of duration less than four weeks over 12 months period were enrolled. Detailed history, clinical examination, and relevant investigations according to a pre-defined diagnostic algorithm were carried out. The patients were followed through their hospital stay till discharge or death.

Results: The mean age was 33.27 (range 13-89) years with male preponderance (67.7%). The most common etiology was neuroparalytic snake envenomation (51.9%), followed by Guillain Barre syndrome (33.1%), constituting 85% of all patients. Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions. We did not encounter any case of acute polio mylitis in adults. In-hospital mortality due to respiratory paralysis was 9%.

Conclusion: Neuroparalytic snakebite and Guillain Barre syndrome were the most common causes of acute flaccid paralysis in adults in our study.

No MeSH data available.


Related in: MedlinePlus