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Acute Flaccid paralysis in adults: Our experience.
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Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions.We did not encounter any case of acute polio mylitis in adults.In-hospital mortality due to respiratory paralysis was 9%.
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PubMed Central - PubMed
Affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.
ABSTRACT
Unlabelled: Acute flaccid paralysis (AFP) is a complex clinical syndrome with a broad array of potential etiologies that vary with age. We present our experience of acute onset lower motor neuron paralysis. Materials and methods: One hundred and thirty-three consecutive adult patients presenting with weakness of duration less than four weeks over 12 months period were enrolled. Detailed history, clinical examination, and relevant investigations according to a pre-defined diagnostic algorithm were carried out. The patients were followed through their hospital stay till discharge or death. Results: The mean age was 33.27 (range 13-89) years with male preponderance (67.7%). The most common etiology was neuroparalytic snake envenomation (51.9%), followed by Guillain Barre syndrome (33.1%), constituting 85% of all patients. Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions. We did not encounter any case of acute polio mylitis in adults. In-hospital mortality due to respiratory paralysis was 9%. Conclusion: Neuroparalytic snakebite and Guillain Barre syndrome were the most common causes of acute flaccid paralysis in adults in our study. No MeSH data available. Related in: MedlinePlus |
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Figure 2: Seasonal distribution of acute flaccid paralysis Mentions: Maximum number of cases of acute flaccid paralysis was encountered during the monsoon period (N = 63). A marked variation in the epidemiology of acute flaccid paralysis was noted over the four seasons. During the monsoon season, majority of cases were related to neurotoxic snake envenomation (81.0%). In contrast, GBS was encountered more commonly during the post-monsoon and winter periods making up 50.0% and 80.0% of the cases, respectively, compared to snakebite, which progressively declined to 20.0% and 6.7%. In the summer months, GBS and snake envenomation were encountered in almost similar frequencies 40.0% and 37.1%, respectively [Figure 2]. This seasonal variability in the etiology of acute flaccid paralysis was statistically significant (P = 0.000). |
View Article: PubMed Central - PubMed
Affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India.
Unlabelled: Acute flaccid paralysis (AFP) is a complex clinical syndrome with a broad array of potential etiologies that vary with age. We present our experience of acute onset lower motor neuron paralysis.
Materials and methods: One hundred and thirty-three consecutive adult patients presenting with weakness of duration less than four weeks over 12 months period were enrolled. Detailed history, clinical examination, and relevant investigations according to a pre-defined diagnostic algorithm were carried out. The patients were followed through their hospital stay till discharge or death.
Results: The mean age was 33.27 (range 13-89) years with male preponderance (67.7%). The most common etiology was neuroparalytic snake envenomation (51.9%), followed by Guillain Barre syndrome (33.1%), constituting 85% of all patients. Hypokalemic paralysis (7.5%) and acute intermittent porphyria (4.5%) were the other important conditions. We did not encounter any case of acute polio mylitis in adults. In-hospital mortality due to respiratory paralysis was 9%.
Conclusion: Neuroparalytic snakebite and Guillain Barre syndrome were the most common causes of acute flaccid paralysis in adults in our study.
No MeSH data available.
