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Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.

Zhang K, Herzog H, Mauler J, Filss C, Okell TW, Kops ER, Tellmann L, Fischer T, Brocke B, Sturm W, Coenen HH, Shah NJ - J. Cereb. Blood Flow Metab. (2014)

Bottom Line: This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL.A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively.Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.

ABSTRACT
Until recently, no direct comparison between [(15)O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL) magnetic resonance imaging (MRI) and [(15)O]water PET. Quantitative CBF values were compared in 10 young healthy male volunteers at baseline conditions. A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively. The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBF between ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [(15)O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

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Images PET-CBF minus ASL-CBF showing differences (P<0.01 uncorr.) in the ranges of 15 to 35 mL per 100 g per minute and −15 to −35 mL per 100 g per minute. Especially in cortical regions CBF measured by ASL is higher than measured by PET. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.
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fig6: Images PET-CBF minus ASL-CBF showing differences (P<0.01 uncorr.) in the ranges of 15 to 35 mL per 100 g per minute and −15 to −35 mL per 100 g per minute. Especially in cortical regions CBF measured by ASL is higher than measured by PET. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.

Mentions: This latter finding is supported by an SPM-based paired t-test of voxel-by-voxel CBF. Across the 10 subjects, absolute differences ranging from 15 to 35 mL per 100 g per minute (P<0.01 uncorr.) were found predominantly in GM (Figure 6).


Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.

Zhang K, Herzog H, Mauler J, Filss C, Okell TW, Kops ER, Tellmann L, Fischer T, Brocke B, Sturm W, Coenen HH, Shah NJ - J. Cereb. Blood Flow Metab. (2014)

Images PET-CBF minus ASL-CBF showing differences (P<0.01 uncorr.) in the ranges of 15 to 35 mL per 100 g per minute and −15 to −35 mL per 100 g per minute. Especially in cortical regions CBF measured by ASL is higher than measured by PET. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126098&req=5

fig6: Images PET-CBF minus ASL-CBF showing differences (P<0.01 uncorr.) in the ranges of 15 to 35 mL per 100 g per minute and −15 to −35 mL per 100 g per minute. Especially in cortical regions CBF measured by ASL is higher than measured by PET. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.
Mentions: This latter finding is supported by an SPM-based paired t-test of voxel-by-voxel CBF. Across the 10 subjects, absolute differences ranging from 15 to 35 mL per 100 g per minute (P<0.01 uncorr.) were found predominantly in GM (Figure 6).

Bottom Line: This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL.A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively.Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.

ABSTRACT
Until recently, no direct comparison between [(15)O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL) magnetic resonance imaging (MRI) and [(15)O]water PET. Quantitative CBF values were compared in 10 young healthy male volunteers at baseline conditions. A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively. The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBF between ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [(15)O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

Show MeSH
Related in: MedlinePlus