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Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.

Zhang K, Herzog H, Mauler J, Filss C, Okell TW, Kops ER, Tellmann L, Fischer T, Brocke B, Sturm W, Coenen HH, Shah NJ - J. Cereb. Blood Flow Metab. (2014)

Bottom Line: This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL.A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively.Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.

ABSTRACT
Until recently, no direct comparison between [(15)O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL) magnetic resonance imaging (MRI) and [(15)O]water PET. Quantitative CBF values were compared in 10 young healthy male volunteers at baseline conditions. A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively. The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBF between ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [(15)O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

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Regional comparison of PET-CBF and ASL-CBF measured across the 10 subjects in eight cortical volumes of interest, the thalamus and the cerebellum. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.
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fig3: Regional comparison of PET-CBF and ASL-CBF measured across the 10 subjects in eight cortical volumes of interest, the thalamus and the cerebellum. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.

Mentions: Figure 3 presents scatter plots of CBF data of eight cortical VOIs, the thalamus and the cerebellum. When testing the correlation between PET-CBF and ASL-CBF with the Pearson correlation, 9 of 10 VOIs showed a significant (P<0.05) result, whereas the Spearman correlation yielded a significant correlation only for four VOIs (Table 1). The Pearson and Spearman correlation coefficients between the PET-CBF and ASL-CBF across all 10 VOIs were both significant (P<0.005) with values of 0.81 and 0.88, respectively.


Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.

Zhang K, Herzog H, Mauler J, Filss C, Okell TW, Kops ER, Tellmann L, Fischer T, Brocke B, Sturm W, Coenen HH, Shah NJ - J. Cereb. Blood Flow Metab. (2014)

Regional comparison of PET-CBF and ASL-CBF measured across the 10 subjects in eight cortical volumes of interest, the thalamus and the cerebellum. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126098&req=5

fig3: Regional comparison of PET-CBF and ASL-CBF measured across the 10 subjects in eight cortical volumes of interest, the thalamus and the cerebellum. ASL, arterial spin labeling; CBF, cerebral blood flow; PET, positron emission tomography.
Mentions: Figure 3 presents scatter plots of CBF data of eight cortical VOIs, the thalamus and the cerebellum. When testing the correlation between PET-CBF and ASL-CBF with the Pearson correlation, 9 of 10 VOIs showed a significant (P<0.05) result, whereas the Spearman correlation yielded a significant correlation only for four VOIs (Table 1). The Pearson and Spearman correlation coefficients between the PET-CBF and ASL-CBF across all 10 VOIs were both significant (P<0.005) with values of 0.81 and 0.88, respectively.

Bottom Line: This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL.A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively.Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

View Article: PubMed Central - PubMed

Affiliation: Institute of Neuroscience and Medicine-4: Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany.

ABSTRACT
Until recently, no direct comparison between [(15)O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL) magnetic resonance imaging (MRI) and [(15)O]water PET. Quantitative CBF values were compared in 10 young healthy male volunteers at baseline conditions. A statistically significant (P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3±6.1 mL and 51.9±7.1 mL per 100 g per minute, respectively. The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBF between ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [(15)O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

Show MeSH
Related in: MedlinePlus