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Emissions generated by sugarcane burning promote genotoxicity in rural workers: a case study in Barretos, Brazil.

Silveira HC, Schmidt-Carrijo M, Seidel EH, Scapulatempo-Neto C, Longatto-Filho A, Carvalho AL, Reis RM, Saldiva PH - Environ Health (2013)

Bottom Line: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.The frequency of micronuclei was higher in the sugar cane workers.The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

View Article: PubMed Central - HTML - PubMed

Affiliation: Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil. henriquecssilveira@gmail.com.

ABSTRACT

Background: To determine the possible genotoxic effect of exposure to the smoke generated by biomass burning on workers involved in manual sugar cane harvesting.

Methods: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.

Results: The frequency of micronuclei was higher in the sugar cane workers. The mean frequency in blood lymphocytes (micronuclei/1000 cells) in the test group was 8.22 versus 1.27 in the control group. The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

Conclusion: Exposure to emissions produced by the burning of sugar cane during harvesting induces genomic instability in workers, indicating the necessity of adopting more advanced techniques of harvesting sugar cane to preserve human health.

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Related in: MedlinePlus

Graph representing of the ROC curve. Receiver operating characteristics curves of the MN frequency in lymphocytes (trace) and the MN frequency in cells exfoliated from the mouth (black). Reference line (gray). The proximity of curves to the upper left corner of the most accurate methods was analyzed.
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Figure 2: Graph representing of the ROC curve. Receiver operating characteristics curves of the MN frequency in lymphocytes (trace) and the MN frequency in cells exfoliated from the mouth (black). Reference line (gray). The proximity of curves to the upper left corner of the most accurate methods was analyzed.

Mentions: Additionally, the Curve Receiver Operating Characteristics (ROC) curves were generated to evaluate the sensitivity and specificity of the two methods (peripheral lymphocytes and exfoliated mucosal cells) in the characterization of the controls and sugar cane workers. Thus, the respective areas of the ROC curves were 0.969 for the MN frequency in lymphocytes and 0.973 for the MN frequencies in exfoliated buccal cells (FigureĀ 2).


Emissions generated by sugarcane burning promote genotoxicity in rural workers: a case study in Barretos, Brazil.

Silveira HC, Schmidt-Carrijo M, Seidel EH, Scapulatempo-Neto C, Longatto-Filho A, Carvalho AL, Reis RM, Saldiva PH - Environ Health (2013)

Graph representing of the ROC curve. Receiver operating characteristics curves of the MN frequency in lymphocytes (trace) and the MN frequency in cells exfoliated from the mouth (black). Reference line (gray). The proximity of curves to the upper left corner of the most accurate methods was analyzed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126064&req=5

Figure 2: Graph representing of the ROC curve. Receiver operating characteristics curves of the MN frequency in lymphocytes (trace) and the MN frequency in cells exfoliated from the mouth (black). Reference line (gray). The proximity of curves to the upper left corner of the most accurate methods was analyzed.
Mentions: Additionally, the Curve Receiver Operating Characteristics (ROC) curves were generated to evaluate the sensitivity and specificity of the two methods (peripheral lymphocytes and exfoliated mucosal cells) in the characterization of the controls and sugar cane workers. Thus, the respective areas of the ROC curves were 0.969 for the MN frequency in lymphocytes and 0.973 for the MN frequencies in exfoliated buccal cells (FigureĀ 2).

Bottom Line: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.The frequency of micronuclei was higher in the sugar cane workers.The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

View Article: PubMed Central - HTML - PubMed

Affiliation: Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil. henriquecssilveira@gmail.com.

ABSTRACT

Background: To determine the possible genotoxic effect of exposure to the smoke generated by biomass burning on workers involved in manual sugar cane harvesting.

Methods: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.

Results: The frequency of micronuclei was higher in the sugar cane workers. The mean frequency in blood lymphocytes (micronuclei/1000 cells) in the test group was 8.22 versus 1.27 in the control group. The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

Conclusion: Exposure to emissions produced by the burning of sugar cane during harvesting induces genomic instability in workers, indicating the necessity of adopting more advanced techniques of harvesting sugar cane to preserve human health.

Show MeSH
Related in: MedlinePlus