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Emissions generated by sugarcane burning promote genotoxicity in rural workers: a case study in Barretos, Brazil.

Silveira HC, Schmidt-Carrijo M, Seidel EH, Scapulatempo-Neto C, Longatto-Filho A, Carvalho AL, Reis RM, Saldiva PH - Environ Health (2013)

Bottom Line: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.The frequency of micronuclei was higher in the sugar cane workers.The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

View Article: PubMed Central - HTML - PubMed

Affiliation: Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil. henriquecssilveira@gmail.com.

ABSTRACT

Background: To determine the possible genotoxic effect of exposure to the smoke generated by biomass burning on workers involved in manual sugar cane harvesting.

Methods: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.

Results: The frequency of micronuclei was higher in the sugar cane workers. The mean frequency in blood lymphocytes (micronuclei/1000 cells) in the test group was 8.22 versus 1.27 in the control group. The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

Conclusion: Exposure to emissions produced by the burning of sugar cane during harvesting induces genomic instability in workers, indicating the necessity of adopting more advanced techniques of harvesting sugar cane to preserve human health.

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Related in: MedlinePlus

Graphic representation of distribution of both groups according to their MN frequency. The MN frequency in lymphocytes (light gray) and the MN frequencies of exfoliated buccal cells (dark gray) were considered for this analysis. (°) indicates discrepancy points, bars indicate percentile values, and lines indicate minimum and maximum standard deviations.
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Figure 1: Graphic representation of distribution of both groups according to their MN frequency. The MN frequency in lymphocytes (light gray) and the MN frequencies of exfoliated buccal cells (dark gray) were considered for this analysis. (°) indicates discrepancy points, bars indicate percentile values, and lines indicate minimum and maximum standard deviations.

Mentions: Adequate smears of exfoliated buccal cells were possible in 43 individuals (16 sugar cane workers and 27 controls) Additional file 1. Again, a higher micronucleus frequency in exfoliated cells was obtained in the group of sugar cane cutters (mean = 22.75, SD = 5.78) compared with the controls (mean = 9.70, SD = 4.76), with a statistically significant p-value <0.001 (Table 2). The distribution of the groups according to their MN frequencies is shown in Figure 1.


Emissions generated by sugarcane burning promote genotoxicity in rural workers: a case study in Barretos, Brazil.

Silveira HC, Schmidt-Carrijo M, Seidel EH, Scapulatempo-Neto C, Longatto-Filho A, Carvalho AL, Reis RM, Saldiva PH - Environ Health (2013)

Graphic representation of distribution of both groups according to their MN frequency. The MN frequency in lymphocytes (light gray) and the MN frequencies of exfoliated buccal cells (dark gray) were considered for this analysis. (°) indicates discrepancy points, bars indicate percentile values, and lines indicate minimum and maximum standard deviations.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126064&req=5

Figure 1: Graphic representation of distribution of both groups according to their MN frequency. The MN frequency in lymphocytes (light gray) and the MN frequencies of exfoliated buccal cells (dark gray) were considered for this analysis. (°) indicates discrepancy points, bars indicate percentile values, and lines indicate minimum and maximum standard deviations.
Mentions: Adequate smears of exfoliated buccal cells were possible in 43 individuals (16 sugar cane workers and 27 controls) Additional file 1. Again, a higher micronucleus frequency in exfoliated cells was obtained in the group of sugar cane cutters (mean = 22.75, SD = 5.78) compared with the controls (mean = 9.70, SD = 4.76), with a statistically significant p-value <0.001 (Table 2). The distribution of the groups according to their MN frequencies is shown in Figure 1.

Bottom Line: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.The frequency of micronuclei was higher in the sugar cane workers.The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

View Article: PubMed Central - HTML - PubMed

Affiliation: Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil. henriquecssilveira@gmail.com.

ABSTRACT

Background: To determine the possible genotoxic effect of exposure to the smoke generated by biomass burning on workers involved in manual sugar cane harvesting.

Methods: The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, comprised of administrative employees of Barretos Cancer Hospital.

Results: The frequency of micronuclei was higher in the sugar cane workers. The mean frequency in blood lymphocytes (micronuclei/1000 cells) in the test group was 8.22 versus 1.27 in the control group. The same effect was observed when exfoliated buccal cells were considered (22.75 and 9.70 micronuclei/1000 cells for sugar cane workers and controls, respectively).

Conclusion: Exposure to emissions produced by the burning of sugar cane during harvesting induces genomic instability in workers, indicating the necessity of adopting more advanced techniques of harvesting sugar cane to preserve human health.

Show MeSH
Related in: MedlinePlus