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Cardiac autonomic dysfunction in type 2 diabetes - effect of hyperglycemia and disease duration.

Tarvainen MP, Laitinen TP, Lipponen JA, Cornforth DJ, Jelinek HF - Front Endocrinol (Lausanne) (2014)

Bottom Line: Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events.Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease.In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Physics, University of Eastern Finland , Kuopio , Finland ; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital , Kuopio , Finland.

ABSTRACT
Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events. The aim of this paper was to examine the associations of blood glucose level (BGL), glycated hemoglobin (HbA1c), and duration of diabetes with cardiac autonomic regulation assessed by HRV analysis. Resting electrocardiogram (ECG), recorded over 20 min in supine position, and clinical measurements of 189 healthy controls and 93 type 2 DM (T2DM) patients were analyzed. HRV was assessed using several time-domain, frequency-domain, and non-linear methods. HRV parameters showed a clear difference between healthy controls and T2DM patients. Hyperglycemia was associated with increase in mean heart rate and decrease in HRV, indicated by negative correlations of BGL and HbA1c with mean RR interval and most of the HRV parameters. Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease. In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients. The most significant decrease in HRV related to diabetes and thus presence of autonomic neuropathy was observed within the first 5-10 years of disease progression.

No MeSH data available.


Related in: MedlinePlus

Polynomial least squares surface fits for the associations of mean RR (top) and total power (bottom) with BGL and disease duration.
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Related In: Results  -  Collection

License
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Figure 4: Polynomial least squares surface fits for the associations of mean RR (top) and total power (bottom) with BGL and disease duration.

Mentions: The associations of mean RR and total spectral power with BGL and disease duration are further illustrated in Figure 4, which shows third order polynomial surface fits on the individual data points. Also from this Figure, it is observed that the decrease of mean RR is stronger along the BGL axis, whereas decrease in total power is more strongly associated with disease duration.


Cardiac autonomic dysfunction in type 2 diabetes - effect of hyperglycemia and disease duration.

Tarvainen MP, Laitinen TP, Lipponen JA, Cornforth DJ, Jelinek HF - Front Endocrinol (Lausanne) (2014)

Polynomial least squares surface fits for the associations of mean RR (top) and total power (bottom) with BGL and disease duration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4126058&req=5

Figure 4: Polynomial least squares surface fits for the associations of mean RR (top) and total power (bottom) with BGL and disease duration.
Mentions: The associations of mean RR and total spectral power with BGL and disease duration are further illustrated in Figure 4, which shows third order polynomial surface fits on the individual data points. Also from this Figure, it is observed that the decrease of mean RR is stronger along the BGL axis, whereas decrease in total power is more strongly associated with disease duration.

Bottom Line: Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events.Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease.In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Physics, University of Eastern Finland , Kuopio , Finland ; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital , Kuopio , Finland.

ABSTRACT
Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events. The aim of this paper was to examine the associations of blood glucose level (BGL), glycated hemoglobin (HbA1c), and duration of diabetes with cardiac autonomic regulation assessed by HRV analysis. Resting electrocardiogram (ECG), recorded over 20 min in supine position, and clinical measurements of 189 healthy controls and 93 type 2 DM (T2DM) patients were analyzed. HRV was assessed using several time-domain, frequency-domain, and non-linear methods. HRV parameters showed a clear difference between healthy controls and T2DM patients. Hyperglycemia was associated with increase in mean heart rate and decrease in HRV, indicated by negative correlations of BGL and HbA1c with mean RR interval and most of the HRV parameters. Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease. In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients. The most significant decrease in HRV related to diabetes and thus presence of autonomic neuropathy was observed within the first 5-10 years of disease progression.

No MeSH data available.


Related in: MedlinePlus