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Genomewide DNA methylation dynamics upon diesel exhaust exposure in asthmatics

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Distribution of probe loading values for principal component 22. The values located at ±3 and ±6 standard deviations are marked.
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Figure 2: Distribution of probe loading values for principal component 22. The values located at ±3 and ±6 standard deviations are marked.

Mentions: Whole genome analysis using PCA followed by denoising revealed that principal component 22, which accounted for 0.5% of the total variance, was significantly associated with the treatment variable: [DE 6hr and 30hr] versus [DE 0hr, FA 0hr, 6hr, and 30hr] (Figure 1). Using loading cutoff of ±6 standard deviations, we found 89 CpG sites to possess the specific pattern of variation (Figure 2). These include genes whose expression is associated with exposure to either diesel exhaust or components of diesel exhaust as reported by literature: CASP7, ATCAY, ABCA1, JAK3, CYFIP2, and NOX2 [1-6].


Genomewide DNA methylation dynamics upon diesel exhaust exposure in asthmatics
Distribution of probe loading values for principal component 22. The values located at ±3 and ±6 standard deviations are marked.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4126045&req=5

Figure 2: Distribution of probe loading values for principal component 22. The values located at ±3 and ±6 standard deviations are marked.
Mentions: Whole genome analysis using PCA followed by denoising revealed that principal component 22, which accounted for 0.5% of the total variance, was significantly associated with the treatment variable: [DE 6hr and 30hr] versus [DE 0hr, FA 0hr, 6hr, and 30hr] (Figure 1). Using loading cutoff of ±6 standard deviations, we found 89 CpG sites to possess the specific pattern of variation (Figure 2). These include genes whose expression is associated with exposure to either diesel exhaust or components of diesel exhaust as reported by literature: CASP7, ATCAY, ABCA1, JAK3, CYFIP2, and NOX2 [1-6].

View Article: PubMed Central - HTML

No MeSH data available.