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Paradigm change to cost-effective predictive and preventive medicine: individual profiling of healthy vasospastic individuals for targeted prevention as the cost-effective personalised medicine

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Proteomics-imaging of blood-biomarkers (ex vivo identification in circulating leukocytes) specific for normal-tension glaucoma (NTG). A. Top: The pathology-specific protein-cluster is completely suppressed in both NTG and vasospasm in contrast to controls. B. Bottom: The marked protein SSP2602 is highly up-regulated in both NTG and vasospasm; this protein normally is not expressed by circulating leukocytes of controls – healthy individuals without vasospasm [4]
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Figure 2: Proteomics-imaging of blood-biomarkers (ex vivo identification in circulating leukocytes) specific for normal-tension glaucoma (NTG). A. Top: The pathology-specific protein-cluster is completely suppressed in both NTG and vasospasm in contrast to controls. B. Bottom: The marked protein SSP2602 is highly up-regulated in both NTG and vasospasm; this protein normally is not expressed by circulating leukocytes of controls – healthy individuals without vasospasm [4]

Mentions: Whereas positive prediction for patients at high risk is important to recognize the pathology before it manifests and at early stages, the negative prediction for individuals at low risk help to avoid undesirable treatments and invasive approaches in the case of non-predisposed individuals. Individual patient profiles are utilised for patient modeling and risk assessment. Blood tests utilizing “omics”-technologies are useful for creating accurate non-invasive positive/negative predictive approaches (Figure 2) [4].


Paradigm change to cost-effective predictive and preventive medicine: individual profiling of healthy vasospastic individuals for targeted prevention as the cost-effective personalised medicine
Proteomics-imaging of blood-biomarkers (ex vivo identification in circulating leukocytes) specific for normal-tension glaucoma (NTG). A. Top: The pathology-specific protein-cluster is completely suppressed in both NTG and vasospasm in contrast to controls. B. Bottom: The marked protein SSP2602 is highly up-regulated in both NTG and vasospasm; this protein normally is not expressed by circulating leukocytes of controls – healthy individuals without vasospasm [4]
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4125882&req=5

Figure 2: Proteomics-imaging of blood-biomarkers (ex vivo identification in circulating leukocytes) specific for normal-tension glaucoma (NTG). A. Top: The pathology-specific protein-cluster is completely suppressed in both NTG and vasospasm in contrast to controls. B. Bottom: The marked protein SSP2602 is highly up-regulated in both NTG and vasospasm; this protein normally is not expressed by circulating leukocytes of controls – healthy individuals without vasospasm [4]
Mentions: Whereas positive prediction for patients at high risk is important to recognize the pathology before it manifests and at early stages, the negative prediction for individuals at low risk help to avoid undesirable treatments and invasive approaches in the case of non-predisposed individuals. Individual patient profiles are utilised for patient modeling and risk assessment. Blood tests utilizing “omics”-technologies are useful for creating accurate non-invasive positive/negative predictive approaches (Figure 2) [4].

View Article: PubMed Central - HTML

No MeSH data available.


Related in: MedlinePlus