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Effect of growth hormone treatment on quality of life in Japanese children with growth hormone deficiency: an analysis from a prospective observational study.

Tanaka T, Hasegawa T, Ozono K, Tanaka H, Kanzaki S, Yokoya S, Chihara K, Iwamoto N, Seino Y - Clin Pediatr Endocrinol (2014)

Bottom Line: Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001).The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003).The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

View Article: PubMed Central - PubMed

Affiliation: Tanaka Growth Clinic, Tokyo, Japan.

ABSTRACT
The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = -9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

No MeSH data available.


Related in: MedlinePlus

Scatter plots showing the correlations between the changes in total (A) andattention problems (B) Youth-Self Report (YSR) scores and the change in heightstandard deviation scores (SDS) after 12 mo of GH treatment in children with GHdeficiency (n = 27).
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fig_003: Scatter plots showing the correlations between the changes in total (A) andattention problems (B) Youth-Self Report (YSR) scores and the change in heightstandard deviation scores (SDS) after 12 mo of GH treatment in children with GHdeficiency (n = 27).

Mentions: The changes in parent-rated CBCL scores were not correlated with the change in height SDSafter 12 mo, whereas several YSR scores were significantly correlated with the change inheight SDS (Table 2Table 2Correlation coefficients highlighting the relationships between the change inheight standard deviation score and the changes in Child Behavior Checklist andYouth-Self Report scores in children with GH deficiency or idiopathic short statureafter 12 mo of study). Specifically, the changes in total, internalizing subscale, and attentionproblems YSR scores were significantly correlated with the change in height SDS inchildren with GHD (p = 0.006, 0.046, and 0.007, respectively) (Fig. 3Fig. 3.


Effect of growth hormone treatment on quality of life in Japanese children with growth hormone deficiency: an analysis from a prospective observational study.

Tanaka T, Hasegawa T, Ozono K, Tanaka H, Kanzaki S, Yokoya S, Chihara K, Iwamoto N, Seino Y - Clin Pediatr Endocrinol (2014)

Scatter plots showing the correlations between the changes in total (A) andattention problems (B) Youth-Self Report (YSR) scores and the change in heightstandard deviation scores (SDS) after 12 mo of GH treatment in children with GHdeficiency (n = 27).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125600&req=5

fig_003: Scatter plots showing the correlations between the changes in total (A) andattention problems (B) Youth-Self Report (YSR) scores and the change in heightstandard deviation scores (SDS) after 12 mo of GH treatment in children with GHdeficiency (n = 27).
Mentions: The changes in parent-rated CBCL scores were not correlated with the change in height SDSafter 12 mo, whereas several YSR scores were significantly correlated with the change inheight SDS (Table 2Table 2Correlation coefficients highlighting the relationships between the change inheight standard deviation score and the changes in Child Behavior Checklist andYouth-Self Report scores in children with GH deficiency or idiopathic short statureafter 12 mo of study). Specifically, the changes in total, internalizing subscale, and attentionproblems YSR scores were significantly correlated with the change in height SDS inchildren with GHD (p = 0.006, 0.046, and 0.007, respectively) (Fig. 3Fig. 3.

Bottom Line: Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001).The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003).The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

View Article: PubMed Central - PubMed

Affiliation: Tanaka Growth Clinic, Tokyo, Japan.

ABSTRACT
The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = -9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

No MeSH data available.


Related in: MedlinePlus