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Effect of growth hormone treatment on quality of life in Japanese children with growth hormone deficiency: an analysis from a prospective observational study.

Tanaka T, Hasegawa T, Ozono K, Tanaka H, Kanzaki S, Yokoya S, Chihara K, Iwamoto N, Seino Y - Clin Pediatr Endocrinol (2014)

Bottom Line: Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001).The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003).The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

View Article: PubMed Central - PubMed

Affiliation: Tanaka Growth Clinic, Tokyo, Japan.

ABSTRACT
The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = -9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

No MeSH data available.


Related in: MedlinePlus

Change from study entry in parent-rated Child Behavior Checklist (CBCL) scores inchildren with GH deficiency (GHD, n = 66) or idiopathic short stature (ISS, n = 61)after 12 mo. Children with GHD received GH treatment for the entire 12 mo, whereaschildren with ISS were not treated. Data are shown as mean ± standard deviation.* Indicates a statistically significant change from study entry (p < 0.05).
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fig_001: Change from study entry in parent-rated Child Behavior Checklist (CBCL) scores inchildren with GH deficiency (GHD, n = 66) or idiopathic short stature (ISS, n = 61)after 12 mo. Children with GHD received GH treatment for the entire 12 mo, whereaschildren with ISS were not treated. Data are shown as mean ± standard deviation.* Indicates a statistically significant change from study entry (p < 0.05).

Mentions: Child Behavior Checklist: Most parent-rated CBCL scores decreased significantly fromstudy entry in both groups of children after 12 mo (Fig. 1Fig. 1.


Effect of growth hormone treatment on quality of life in Japanese children with growth hormone deficiency: an analysis from a prospective observational study.

Tanaka T, Hasegawa T, Ozono K, Tanaka H, Kanzaki S, Yokoya S, Chihara K, Iwamoto N, Seino Y - Clin Pediatr Endocrinol (2014)

Change from study entry in parent-rated Child Behavior Checklist (CBCL) scores inchildren with GH deficiency (GHD, n = 66) or idiopathic short stature (ISS, n = 61)after 12 mo. Children with GHD received GH treatment for the entire 12 mo, whereaschildren with ISS were not treated. Data are shown as mean ± standard deviation.* Indicates a statistically significant change from study entry (p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125600&req=5

fig_001: Change from study entry in parent-rated Child Behavior Checklist (CBCL) scores inchildren with GH deficiency (GHD, n = 66) or idiopathic short stature (ISS, n = 61)after 12 mo. Children with GHD received GH treatment for the entire 12 mo, whereaschildren with ISS were not treated. Data are shown as mean ± standard deviation.* Indicates a statistically significant change from study entry (p < 0.05).
Mentions: Child Behavior Checklist: Most parent-rated CBCL scores decreased significantly fromstudy entry in both groups of children after 12 mo (Fig. 1Fig. 1.

Bottom Line: Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001).The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003).The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

View Article: PubMed Central - PubMed

Affiliation: Tanaka Growth Clinic, Tokyo, Japan.

ABSTRACT
The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = -9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

No MeSH data available.


Related in: MedlinePlus