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How to design in situ studies: an evaluation of experimental protocols.

Sung YH, Kim HY, Son HH, Chang J - Restor Dent Endod (2014)

Bottom Line: Multiple variables were analyzed in relation to the publication types, participant characteristics, specimen and appliance factors, and other conditions.It will be possible to establish standardized in situ protocols according to the research topics.Furthermore, data collaboration from comparable studies would be enhanced by homogeneous study designs.

View Article: PubMed Central - PubMed

Affiliation: Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute, Seoul, Korea.

ABSTRACT

Objectives: Designing in situ models for caries research is a demanding procedure, as both clinical and laboratory parameters need to be incorporated in a single study. This study aimed to construct an informative guideline for planning in situ models relevant to preexisting caries studies.

Materials and methods: An electronic literature search of the PubMed database was performed. A total 191 of full articles written in English were included and data were extracted from materials and methods. Multiple variables were analyzed in relation to the publication types, participant characteristics, specimen and appliance factors, and other conditions. Frequencies and percentages were displayed to summarize the data and the Pearson's chi-square test was used to assess a statistical significance (p < 0.05).

Results: There were many parameters commonly included in the majority of in situ models such as inclusion criteria, sample sizes, sample allocation methods, tooth types, intraoral appliance types, sterilization methods, study periods, outcome measures, experimental interventions, etc. Interrelationships existed between the main research topics and some parameters (outcome measures and sample allocation methods) among the evaluated articles.

Conclusions: It will be possible to establish standardized in situ protocols according to the research topics. Furthermore, data collaboration from comparable studies would be enhanced by homogeneous study designs.

No MeSH data available.


Related in: MedlinePlus

Number of in situ caries studies published from 2003 to 2012 according to the main topics. Demineralization, only demineralization of tooth was dealt in the study; Remineralization, remineralization of tooth was included in the study (whether demineralization was included or not), but erosion was not included; Erosion, erosion was included whether other topics were included or not; Others, articles in this category mainly dealt with the abrasive effects of dental products such as toothpastes and tooth whitening agents.
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Figure 2: Number of in situ caries studies published from 2003 to 2012 according to the main topics. Demineralization, only demineralization of tooth was dealt in the study; Remineralization, remineralization of tooth was included in the study (whether demineralization was included or not), but erosion was not included; Erosion, erosion was included whether other topics were included or not; Others, articles in this category mainly dealt with the abrasive effects of dental products such as toothpastes and tooth whitening agents.

Mentions: The journals with in situ studies published are listed in Table 1. Caries Research was the journal with the highest number of articles of published in situ caries studies (n = 63, 33.0%). The yearly distribution of publications of in situ caries studies according to their main topics is shown in Figure 2.


How to design in situ studies: an evaluation of experimental protocols.

Sung YH, Kim HY, Son HH, Chang J - Restor Dent Endod (2014)

Number of in situ caries studies published from 2003 to 2012 according to the main topics. Demineralization, only demineralization of tooth was dealt in the study; Remineralization, remineralization of tooth was included in the study (whether demineralization was included or not), but erosion was not included; Erosion, erosion was included whether other topics were included or not; Others, articles in this category mainly dealt with the abrasive effects of dental products such as toothpastes and tooth whitening agents.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125579&req=5

Figure 2: Number of in situ caries studies published from 2003 to 2012 according to the main topics. Demineralization, only demineralization of tooth was dealt in the study; Remineralization, remineralization of tooth was included in the study (whether demineralization was included or not), but erosion was not included; Erosion, erosion was included whether other topics were included or not; Others, articles in this category mainly dealt with the abrasive effects of dental products such as toothpastes and tooth whitening agents.
Mentions: The journals with in situ studies published are listed in Table 1. Caries Research was the journal with the highest number of articles of published in situ caries studies (n = 63, 33.0%). The yearly distribution of publications of in situ caries studies according to their main topics is shown in Figure 2.

Bottom Line: Multiple variables were analyzed in relation to the publication types, participant characteristics, specimen and appliance factors, and other conditions.It will be possible to establish standardized in situ protocols according to the research topics.Furthermore, data collaboration from comparable studies would be enhanced by homogeneous study designs.

View Article: PubMed Central - PubMed

Affiliation: Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute, Seoul, Korea.

ABSTRACT

Objectives: Designing in situ models for caries research is a demanding procedure, as both clinical and laboratory parameters need to be incorporated in a single study. This study aimed to construct an informative guideline for planning in situ models relevant to preexisting caries studies.

Materials and methods: An electronic literature search of the PubMed database was performed. A total 191 of full articles written in English were included and data were extracted from materials and methods. Multiple variables were analyzed in relation to the publication types, participant characteristics, specimen and appliance factors, and other conditions. Frequencies and percentages were displayed to summarize the data and the Pearson's chi-square test was used to assess a statistical significance (p < 0.05).

Results: There were many parameters commonly included in the majority of in situ models such as inclusion criteria, sample sizes, sample allocation methods, tooth types, intraoral appliance types, sterilization methods, study periods, outcome measures, experimental interventions, etc. Interrelationships existed between the main research topics and some parameters (outcome measures and sample allocation methods) among the evaluated articles.

Conclusions: It will be possible to establish standardized in situ protocols according to the research topics. Furthermore, data collaboration from comparable studies would be enhanced by homogeneous study designs.

No MeSH data available.


Related in: MedlinePlus