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Paclitaxel- and/or cisplatin-induced ocular neurotoxicity: a case report and literature review.

Li Y, Li Y, Li J, Pi G, Tan W - Onco Targets Ther (2014)

Bottom Line: Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors.A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports.Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, People's Republic of China.

ABSTRACT
Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors. Both may cause moderate or severe neurotoxicity, but ocular neurotoxicity is also occasionally reported. A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports. Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.

No MeSH data available.


Related in: MedlinePlus

Color wash and dose-volume histogram.Note: The radiation dose distribution at the optic chiasm (red solid line), and the left (green solid line) and right (purple solid line) optic nerves are shown in a color wash (A) and dose-volume histogram (B).
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f1-ott-7-1361: Color wash and dose-volume histogram.Note: The radiation dose distribution at the optic chiasm (red solid line), and the left (green solid line) and right (purple solid line) optic nerves are shown in a color wash (A) and dose-volume histogram (B).

Mentions: The patient provided written informed consent for this case report. A 56-year-old male patient was diagnosed pathologically with a low-differentiated non-keratinized squamous cell via a nasopharyngeal biopsy performed using electronic nasopharyngeal endoscopy. The primary tumor had invaded locally, including the cervical lymph nodes. Based on the 2010 American Joint Committee on Cancer staging system, the tumor was stage III with T2N2M0. Intensity-modulated radiotherapy (IMRT) was delivered at three doses from July to August 2013 according to our departmental protocol (Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, People’s Republic of China).5 The radiation dose to gross primary tumor and positive lymph nodes in the neck, high-risk region, and low-risk elective nodal region were 70 Gy, 60.3 Gy, and 54 Gy, respectively. IMRT was delivered with 30 daily fractions in 6 weeks (five fractions per week). The maximal radiation dose to the optic chiasm and the left and right optic nerves were 32.1 Gy, 16.7 Gy, and 17.7 Gy, respectively (Figure 1). Complete response was confirmed by both magnetic resonance imaging (MRI) and electronic nasopharyngeal endoscope 2 months after completing radiotherapy. In addition, patient also has well controlled primary hypertension and chronic hepatitis B.


Paclitaxel- and/or cisplatin-induced ocular neurotoxicity: a case report and literature review.

Li Y, Li Y, Li J, Pi G, Tan W - Onco Targets Ther (2014)

Color wash and dose-volume histogram.Note: The radiation dose distribution at the optic chiasm (red solid line), and the left (green solid line) and right (purple solid line) optic nerves are shown in a color wash (A) and dose-volume histogram (B).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125372&req=5

f1-ott-7-1361: Color wash and dose-volume histogram.Note: The radiation dose distribution at the optic chiasm (red solid line), and the left (green solid line) and right (purple solid line) optic nerves are shown in a color wash (A) and dose-volume histogram (B).
Mentions: The patient provided written informed consent for this case report. A 56-year-old male patient was diagnosed pathologically with a low-differentiated non-keratinized squamous cell via a nasopharyngeal biopsy performed using electronic nasopharyngeal endoscopy. The primary tumor had invaded locally, including the cervical lymph nodes. Based on the 2010 American Joint Committee on Cancer staging system, the tumor was stage III with T2N2M0. Intensity-modulated radiotherapy (IMRT) was delivered at three doses from July to August 2013 according to our departmental protocol (Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, People’s Republic of China).5 The radiation dose to gross primary tumor and positive lymph nodes in the neck, high-risk region, and low-risk elective nodal region were 70 Gy, 60.3 Gy, and 54 Gy, respectively. IMRT was delivered with 30 daily fractions in 6 weeks (five fractions per week). The maximal radiation dose to the optic chiasm and the left and right optic nerves were 32.1 Gy, 16.7 Gy, and 17.7 Gy, respectively (Figure 1). Complete response was confirmed by both magnetic resonance imaging (MRI) and electronic nasopharyngeal endoscope 2 months after completing radiotherapy. In addition, patient also has well controlled primary hypertension and chronic hepatitis B.

Bottom Line: Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors.A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports.Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, People's Republic of China.

ABSTRACT
Paclitaxel (PTX) and/or cisplatin (CDDP), as important cytotoxic anti-cancer agents, are widely used to treat various solid tumors. Both may cause moderate or severe neurotoxicity, but ocular neurotoxicity is also occasionally reported. A patient diagnosed with nasopharyngeal cancer suffering acute ocular neurotoxicity 10 days after paclitaxel and CDDP administration at the recommended dose is described in the present case report, and PTX- and/or CDDP-induced ocular neurotoxicity are summarized according to previous reports. Possible mechanisms and the potential diagnostic, therapeutic and predictive strategies of PTX- and/or CDDP-induced ocular neurotoxicity are reviewed, to help the oncologist to take the infrequent toxicity of cytotoxic drugs into account and improve patient safety during anti-cancer therapy.

No MeSH data available.


Related in: MedlinePlus