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Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.

Kiani MJ, Harun FK, Ahmadi MT, Rahmani M, Saeidmanesh M, Zare M - Nanoscale Res Lett (2014)

Bottom Line: Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET).Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane.Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.

ABSTRACT
Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

No MeSH data available.


Extracted experimental data for membrane thickness effect and G-Vg characteristic of proposed conductance model. (a) Extracted experimental data for membrane thickness effect of biomimetic membrane-coated graphene biosensor. (b)G-Vg characteristic of proposed conductance model with experimental data [10] for 10-μM membrane thickness.
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Figure 8: Extracted experimental data for membrane thickness effect and G-Vg characteristic of proposed conductance model. (a) Extracted experimental data for membrane thickness effect of biomimetic membrane-coated graphene biosensor. (b)G-Vg characteristic of proposed conductance model with experimental data [10] for 10-μM membrane thickness.

Mentions: In Figure 8b, all the theoretical GLP-Vg characteristics of graphene-based GFET with LLP = 10 μM are plotted. Comparing Figures 8a and b, it can be seen that the biomimetic membrane-coated graphene biosensor model according to the suggested parameters (α and β) indicates the same trends as those reported by [10]. In both the experimental and theoretical data, there is a clear shift in Vg,min with increasing membrane thickness. Comparison of the experimental data depicted with the theoretical data in Figure 8 shows that a 10 μM membrane thickness caused a 10-meV shift in Vg,min.


Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.

Kiani MJ, Harun FK, Ahmadi MT, Rahmani M, Saeidmanesh M, Zare M - Nanoscale Res Lett (2014)

Extracted experimental data for membrane thickness effect and G-Vg characteristic of proposed conductance model. (a) Extracted experimental data for membrane thickness effect of biomimetic membrane-coated graphene biosensor. (b)G-Vg characteristic of proposed conductance model with experimental data [10] for 10-μM membrane thickness.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125348&req=5

Figure 8: Extracted experimental data for membrane thickness effect and G-Vg characteristic of proposed conductance model. (a) Extracted experimental data for membrane thickness effect of biomimetic membrane-coated graphene biosensor. (b)G-Vg characteristic of proposed conductance model with experimental data [10] for 10-μM membrane thickness.
Mentions: In Figure 8b, all the theoretical GLP-Vg characteristics of graphene-based GFET with LLP = 10 μM are plotted. Comparing Figures 8a and b, it can be seen that the biomimetic membrane-coated graphene biosensor model according to the suggested parameters (α and β) indicates the same trends as those reported by [10]. In both the experimental and theoretical data, there is a clear shift in Vg,min with increasing membrane thickness. Comparison of the experimental data depicted with the theoretical data in Figure 8 shows that a 10 μM membrane thickness caused a 10-meV shift in Vg,min.

Bottom Line: Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET).Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane.Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.

ABSTRACT
Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

No MeSH data available.