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Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.

Kiani MJ, Harun FK, Ahmadi MT, Rahmani M, Saeidmanesh M, Zare M - Nanoscale Res Lett (2014)

Bottom Line: Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET).Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane.Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.

ABSTRACT
Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

No MeSH data available.


Comparison between bipolar transfer curve of conductance model (blue line) and experimental extracted data (red line) for neutral membrane.
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Figure 3: Comparison between bipolar transfer curve of conductance model (blue line) and experimental extracted data (red line) for neutral membrane.

Mentions: where x = (E - Eg)/kBT and the normalized Fermi energy is η = (EF - Eg)/kBT. Thus, the general conductance model of single-layer graphene obtained is similar to that of silicon reported by Gunlycke [16]. According to the conductance-gate voltage characteristic of graphene-based electrolyte-gated graphene field effect transistor (GFET) devices, the performance of biomimetic membrane-coated graphene biosensors can be estimated through this equation. By assuming that the source and substrate terminals are detained in ground potential, the channel region has the characteristics of the resistor in the small voltage between the source and drain (VDS). As shown in Figure 3, the performance of a lipid bilayer-based sensor based on graphene nanostructure is assessed by the conductance characteristic. Before the electrolyte solution has been added, pure water as a water-gated ambipolar GFET was added into the membrane to measure the transfer curve. There is substantial agreement between the proposed model of the lipid bilayer-based biosensor and the experimental result which is extracted from the reference [10].


Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.

Kiani MJ, Harun FK, Ahmadi MT, Rahmani M, Saeidmanesh M, Zare M - Nanoscale Res Lett (2014)

Comparison between bipolar transfer curve of conductance model (blue line) and experimental extracted data (red line) for neutral membrane.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125348&req=5

Figure 3: Comparison between bipolar transfer curve of conductance model (blue line) and experimental extracted data (red line) for neutral membrane.
Mentions: where x = (E - Eg)/kBT and the normalized Fermi energy is η = (EF - Eg)/kBT. Thus, the general conductance model of single-layer graphene obtained is similar to that of silicon reported by Gunlycke [16]. According to the conductance-gate voltage characteristic of graphene-based electrolyte-gated graphene field effect transistor (GFET) devices, the performance of biomimetic membrane-coated graphene biosensors can be estimated through this equation. By assuming that the source and substrate terminals are detained in ground potential, the channel region has the characteristics of the resistor in the small voltage between the source and drain (VDS). As shown in Figure 3, the performance of a lipid bilayer-based sensor based on graphene nanostructure is assessed by the conductance characteristic. Before the electrolyte solution has been added, pure water as a water-gated ambipolar GFET was added into the membrane to measure the transfer curve. There is substantial agreement between the proposed model of the lipid bilayer-based biosensor and the experimental result which is extracted from the reference [10].

Bottom Line: Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET).Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane.Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.

ABSTRACT
Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

No MeSH data available.