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Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.

Kiani MJ, Harun FK, Ahmadi MT, Rahmani M, Saeidmanesh M, Zare M - Nanoscale Res Lett (2014)

Bottom Line: Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET).Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane.Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.

ABSTRACT
Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

No MeSH data available.


Structure of phospholipid bilayer.
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Figure 2: Structure of phospholipid bilayer.

Mentions: Graphene has attractive electrical properties such as the ability to continuously tune the charge carriers from holes to electrons, high mobility, and high-carrier velocity [5-8]. The charge carrier (electron) in graphene can be explained by electron propagation through the honeycomb lattice of graphene that develops after the electrons lose their effective mass, which yields quasi-particles called ‘Dirac fermions’ [9]. These Dirac fermion particles are hard to imagine because they have no known analogies [9]. They can be illustrated by a combination of both Dirac and Schrödinger equations. In addition, graphene requires current to be effective, precise, and faster than any other metal on biosensors, in the same way as a biomimetic membrane-coated graphene biosensor [10]. Several types of animal and plant cells are surrounded with a two-layer covering, which is called the phospholipid bilayer [11]. As shown in Figure 2, the molecules that make up the phospholipid bilayer, called phospholipids, organize themselves into two corresponding layers, shaping a covering that can only be infiltrated by certain kinds of substances [11]. This gives the cell an apparent barrier and keeps useless materials out [12].


Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.

Kiani MJ, Harun FK, Ahmadi MT, Rahmani M, Saeidmanesh M, Zare M - Nanoscale Res Lett (2014)

Structure of phospholipid bilayer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125348&req=5

Figure 2: Structure of phospholipid bilayer.
Mentions: Graphene has attractive electrical properties such as the ability to continuously tune the charge carriers from holes to electrons, high mobility, and high-carrier velocity [5-8]. The charge carrier (electron) in graphene can be explained by electron propagation through the honeycomb lattice of graphene that develops after the electrons lose their effective mass, which yields quasi-particles called ‘Dirac fermions’ [9]. These Dirac fermion particles are hard to imagine because they have no known analogies [9]. They can be illustrated by a combination of both Dirac and Schrödinger equations. In addition, graphene requires current to be effective, precise, and faster than any other metal on biosensors, in the same way as a biomimetic membrane-coated graphene biosensor [10]. Several types of animal and plant cells are surrounded with a two-layer covering, which is called the phospholipid bilayer [11]. As shown in Figure 2, the molecules that make up the phospholipid bilayer, called phospholipids, organize themselves into two corresponding layers, shaping a covering that can only be infiltrated by certain kinds of substances [11]. This gives the cell an apparent barrier and keeps useless materials out [12].

Bottom Line: Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET).Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane.Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.

ABSTRACT
Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.

No MeSH data available.