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Plasma levels of S100B in preeclampsia and association with possible central nervous system effects.

Bergman L, Akhter T, Wikström AK, Wikström J, Naessen T, Åkerud H - Am. J. Hypertens. (2014)

Bottom Line: The purpose of this study was to compare levels of S100B in women with preeclampsia with levels in healthy pregnant control subjects and furthermore to analyze levels of S100B in relation to possible CNS effects.The main outcome measures were plasma levels of S100B and possible CNS effects.Levels of S100B were significantly higher among women with preeclampsia than among control subjects (0.12 µg/L vs. 0.07 µg/L; P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Centre for Clinical Research, Dalarna, Sweden; lina.bergman@kbh.uu.se.

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Receiver operator characteristics (ROC) curve. The ROC curve shows optimal cutoff level of S100B (µg/L) to discriminate between women with preeclampsia and women with normal pregnancies. The area under curve (AUC) is 0.706.
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Figure 2: Receiver operator characteristics (ROC) curve. The ROC curve shows optimal cutoff level of S100B (µg/L) to discriminate between women with preeclampsia and women with normal pregnancies. The area under curve (AUC) is 0.706.

Mentions: The association between preeclampsia and high levels of S100B was analyzed further. A receiver operator characteristics curve for levels of S100B and risk of preeclampsia was constructed, and a cutoff value of 0.14 µg/L for levels of S100B was chosen to optimize sensitivity (44%) and specificity (86%). The area under the curve was 0.71 (Figure 2). When levels of S100B were divided into 2 groups based on the cutoff value and used in a bivariable regression analysis, the results confirmed an association between preeclampsia and high levels of S100B (OR = 4.71; 95% confidence interval (CI) = 1.79–12.37). In a multivariable logistic regression analysis adjusted for parity and body mass index, high levels of S100B still remained as an independent factor associated with preeclampsia (OR = 5.56; 95% CI = 1.91–16.19) (Table 2). The results were confirmed in a 2-fold cross validation where levels of S100B remained as an independent factor associated with preeclampsia (data not shown).


Plasma levels of S100B in preeclampsia and association with possible central nervous system effects.

Bergman L, Akhter T, Wikström AK, Wikström J, Naessen T, Åkerud H - Am. J. Hypertens. (2014)

Receiver operator characteristics (ROC) curve. The ROC curve shows optimal cutoff level of S100B (µg/L) to discriminate between women with preeclampsia and women with normal pregnancies. The area under curve (AUC) is 0.706.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4125339&req=5

Figure 2: Receiver operator characteristics (ROC) curve. The ROC curve shows optimal cutoff level of S100B (µg/L) to discriminate between women with preeclampsia and women with normal pregnancies. The area under curve (AUC) is 0.706.
Mentions: The association between preeclampsia and high levels of S100B was analyzed further. A receiver operator characteristics curve for levels of S100B and risk of preeclampsia was constructed, and a cutoff value of 0.14 µg/L for levels of S100B was chosen to optimize sensitivity (44%) and specificity (86%). The area under the curve was 0.71 (Figure 2). When levels of S100B were divided into 2 groups based on the cutoff value and used in a bivariable regression analysis, the results confirmed an association between preeclampsia and high levels of S100B (OR = 4.71; 95% confidence interval (CI) = 1.79–12.37). In a multivariable logistic regression analysis adjusted for parity and body mass index, high levels of S100B still remained as an independent factor associated with preeclampsia (OR = 5.56; 95% CI = 1.91–16.19) (Table 2). The results were confirmed in a 2-fold cross validation where levels of S100B remained as an independent factor associated with preeclampsia (data not shown).

Bottom Line: The purpose of this study was to compare levels of S100B in women with preeclampsia with levels in healthy pregnant control subjects and furthermore to analyze levels of S100B in relation to possible CNS effects.The main outcome measures were plasma levels of S100B and possible CNS effects.Levels of S100B were significantly higher among women with preeclampsia than among control subjects (0.12 µg/L vs. 0.07 µg/L; P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Centre for Clinical Research, Dalarna, Sweden; lina.bergman@kbh.uu.se.

Show MeSH
Related in: MedlinePlus