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Recurrent arterial and venous thromboemboli as initial presentation of acute promyelocytic leukemia.

Trottier-Tellier F, Durand M, Kolan C, Wistaff R, Nguyen PV, Laskine M - J Clin Med Res (2014)

Bottom Line: This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up.To our knowledge, this presentation is the second case in the literature.We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

View Article: PubMed Central - PubMed

Affiliation: Universite de Montreal, Montreal, Canada.

ABSTRACT
We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

No MeSH data available.


Related in: MedlinePlus

A normocellular bone marrow is observed after 1 month of treatment.
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Figure 3: A normocellular bone marrow is observed after 1 month of treatment.

Mentions: An induction treatment of all trans-retinoic acid (ATRA) and arsenic was immediately started. The patient had an excellent clinical evolution without evidence of the retinoic acid syndrome. As planned in our hospital protocol, a control bone marrow biopsy was performed after 1 month of induction treatment and confirmed a hematologic complete remission (Fig. 3).


Recurrent arterial and venous thromboemboli as initial presentation of acute promyelocytic leukemia.

Trottier-Tellier F, Durand M, Kolan C, Wistaff R, Nguyen PV, Laskine M - J Clin Med Res (2014)

A normocellular bone marrow is observed after 1 month of treatment.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125336&req=5

Figure 3: A normocellular bone marrow is observed after 1 month of treatment.
Mentions: An induction treatment of all trans-retinoic acid (ATRA) and arsenic was immediately started. The patient had an excellent clinical evolution without evidence of the retinoic acid syndrome. As planned in our hospital protocol, a control bone marrow biopsy was performed after 1 month of induction treatment and confirmed a hematologic complete remission (Fig. 3).

Bottom Line: This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up.To our knowledge, this presentation is the second case in the literature.We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

View Article: PubMed Central - PubMed

Affiliation: Universite de Montreal, Montreal, Canada.

ABSTRACT
We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

No MeSH data available.


Related in: MedlinePlus