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Recurrent arterial and venous thromboemboli as initial presentation of acute promyelocytic leukemia.

Trottier-Tellier F, Durand M, Kolan C, Wistaff R, Nguyen PV, Laskine M - J Clin Med Res (2014)

Bottom Line: This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up.To our knowledge, this presentation is the second case in the literature.We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

View Article: PubMed Central - PubMed

Affiliation: Universite de Montreal, Montreal, Canada.

ABSTRACT
We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

No MeSH data available.


Related in: MedlinePlus

(a, b) Bone marrow biopsy result compatible with AML showing a hypercellular marrow with excess of immature myeloid cells and the presence of rare megacaryocytes.
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Figure 2: (a, b) Bone marrow biopsy result compatible with AML showing a hypercellular marrow with excess of immature myeloid cells and the presence of rare megacaryocytes.

Mentions: Given the unexplained severe anemia and neutropenia, a bone marrow biopsy was performed. Preliminary result showed 40% blast cells, absence of AUER rod but strongly positive peroxidase stain, suggestive of acute myeloid leukemia of undefined classification. Molecular analysis confirmed the t(15:17) genetic anomaly and the diagnosis of low risk acute promyelocytic leukemia (APL) with secondary multiple arterial and venous thrombosis was done (Fig. 2).


Recurrent arterial and venous thromboemboli as initial presentation of acute promyelocytic leukemia.

Trottier-Tellier F, Durand M, Kolan C, Wistaff R, Nguyen PV, Laskine M - J Clin Med Res (2014)

(a, b) Bone marrow biopsy result compatible with AML showing a hypercellular marrow with excess of immature myeloid cells and the presence of rare megacaryocytes.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125336&req=5

Figure 2: (a, b) Bone marrow biopsy result compatible with AML showing a hypercellular marrow with excess of immature myeloid cells and the presence of rare megacaryocytes.
Mentions: Given the unexplained severe anemia and neutropenia, a bone marrow biopsy was performed. Preliminary result showed 40% blast cells, absence of AUER rod but strongly positive peroxidase stain, suggestive of acute myeloid leukemia of undefined classification. Molecular analysis confirmed the t(15:17) genetic anomaly and the diagnosis of low risk acute promyelocytic leukemia (APL) with secondary multiple arterial and venous thrombosis was done (Fig. 2).

Bottom Line: This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up.To our knowledge, this presentation is the second case in the literature.We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

View Article: PubMed Central - PubMed

Affiliation: Universite de Montreal, Montreal, Canada.

ABSTRACT
We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

No MeSH data available.


Related in: MedlinePlus