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Effect of sitagliptin on lipid profile in patients with type 2 diabetes mellitus.

Shigematsu E, Yamakawa T, Kadonosono K, Terauchi Y - J Clin Med Res (2014)

Bottom Line: Both plasma glucose and HbA1c were significantly decreased.Multivariate analysis showed a significant decrease of the TC, LDL-C and non-HDL-C levels in the high TG group (≥ 150 mg/dL), as well as a significant decrease of TC and LDL-C in patients using strong statins.The results suggested that sitagliptin caused a significant decrease of TC, LDL-C and non-HDL-C, particularly in patients with high baseline TG levels and those using strong statins.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Diabetes, Yokohama City University Medical Center, Yokohama, Japan.

ABSTRACT

Background: Animal studies have demonstrated that an inhibition of DPP-4 has an impact on the secretion of cholesterol and apoB by the small intestine. However, there is no consensus about the changes of the lipid profile following administration of sitagliptin.

Methods: Accordingly, we treated patients who had type 2 diabetes complicated by dyslipidemia with sitagliptin and evaluated its effects on the profile of lipid parameters. A total of 248 outpatients with type 2 diabetes complicated by dyslipidemia were treated with sitagliptin at a daily dose of 50 mg. The levels and percent changes of lipid and glucose metabolism markers were measured at baseline and at 12 weeks after the initiation of treatment.

Results: Both plasma glucose and HbA1c were significantly decreased. Among the lipid parameters, total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) showed a significant decrease (TC 3.6±15.6%, non-HDL-C 2.9±19.7%; P < 0.05). Stratified analysis revealed a significant decrease of TC, low-density lipoprotein cholesterol (LDL-C) and non-HDL-C in the high triglyceride (TG) group (≥ 150 mg/dL) (P < 0.05). Analysis stratified by demographic factors demonstrated significant differences in the changes of TC, LDL-C and non-HDL-C. Multivariate analysis showed a significant decrease of the TC, LDL-C and non-HDL-C levels in the high TG group (≥ 150 mg/dL), as well as a significant decrease of TC and LDL-C in patients using strong statins.

Conclusions: The results suggested that sitagliptin caused a significant decrease of TC, LDL-C and non-HDL-C, particularly in patients with high baseline TG levels and those using strong statins.

No MeSH data available.


Related in: MedlinePlus

The correlation between change of HbA1c and lipid at week 12. TC: total cholesterol; LDL-C: LDL-cholesterol; non-HDL-C: non-HDL-cholesterol.
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Figure 1: The correlation between change of HbA1c and lipid at week 12. TC: total cholesterol; LDL-C: LDL-cholesterol; non-HDL-C: non-HDL-cholesterol.

Mentions: Next in order to elucidate whether blood glucose reduction affects lipid change, we investigate the link between change of HbA1c and lipid. As shown in Figure 1, there are no associations between HbA1c and change of TC, LDL-C, HDL-C, TG and non-HDL-C levels at 12 weeks (Fig. 1).


Effect of sitagliptin on lipid profile in patients with type 2 diabetes mellitus.

Shigematsu E, Yamakawa T, Kadonosono K, Terauchi Y - J Clin Med Res (2014)

The correlation between change of HbA1c and lipid at week 12. TC: total cholesterol; LDL-C: LDL-cholesterol; non-HDL-C: non-HDL-cholesterol.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125327&req=5

Figure 1: The correlation between change of HbA1c and lipid at week 12. TC: total cholesterol; LDL-C: LDL-cholesterol; non-HDL-C: non-HDL-cholesterol.
Mentions: Next in order to elucidate whether blood glucose reduction affects lipid change, we investigate the link between change of HbA1c and lipid. As shown in Figure 1, there are no associations between HbA1c and change of TC, LDL-C, HDL-C, TG and non-HDL-C levels at 12 weeks (Fig. 1).

Bottom Line: Both plasma glucose and HbA1c were significantly decreased.Multivariate analysis showed a significant decrease of the TC, LDL-C and non-HDL-C levels in the high TG group (≥ 150 mg/dL), as well as a significant decrease of TC and LDL-C in patients using strong statins.The results suggested that sitagliptin caused a significant decrease of TC, LDL-C and non-HDL-C, particularly in patients with high baseline TG levels and those using strong statins.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Diabetes, Yokohama City University Medical Center, Yokohama, Japan.

ABSTRACT

Background: Animal studies have demonstrated that an inhibition of DPP-4 has an impact on the secretion of cholesterol and apoB by the small intestine. However, there is no consensus about the changes of the lipid profile following administration of sitagliptin.

Methods: Accordingly, we treated patients who had type 2 diabetes complicated by dyslipidemia with sitagliptin and evaluated its effects on the profile of lipid parameters. A total of 248 outpatients with type 2 diabetes complicated by dyslipidemia were treated with sitagliptin at a daily dose of 50 mg. The levels and percent changes of lipid and glucose metabolism markers were measured at baseline and at 12 weeks after the initiation of treatment.

Results: Both plasma glucose and HbA1c were significantly decreased. Among the lipid parameters, total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) showed a significant decrease (TC 3.6±15.6%, non-HDL-C 2.9±19.7%; P < 0.05). Stratified analysis revealed a significant decrease of TC, low-density lipoprotein cholesterol (LDL-C) and non-HDL-C in the high triglyceride (TG) group (≥ 150 mg/dL) (P < 0.05). Analysis stratified by demographic factors demonstrated significant differences in the changes of TC, LDL-C and non-HDL-C. Multivariate analysis showed a significant decrease of the TC, LDL-C and non-HDL-C levels in the high TG group (≥ 150 mg/dL), as well as a significant decrease of TC and LDL-C in patients using strong statins.

Conclusions: The results suggested that sitagliptin caused a significant decrease of TC, LDL-C and non-HDL-C, particularly in patients with high baseline TG levels and those using strong statins.

No MeSH data available.


Related in: MedlinePlus