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Low physical activity level and short sleep duration are associated with an increased cardio-metabolic risk profile: a longitudinal study in 8-11 year old Danish children.

Hjorth MF, Chaput JP, Damsgaard CT, Dalskov SM, Andersen R, Astrup A, Michaelsen KF, Tetens I, Ritz C, Sjödin A - PLoS ONE (2014)

Bottom Line: In the cross-sectional analysis, physical activity was negatively associated with the MetS-score (P<0.03).Further adjusting for fat mass index while removing waist circumference from the MetS-score rendered the associations no longer statistically significant (all P>0.17).Children in the most favorable tertiles of changes in moderate-to-vigorous physical activity, sleep duration and sedentary time during the 200-day follow-up period had an improved MetS-score relative to children in the opposite tertiles (P = 0.005).

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Background: As cardio-metabolic risk tracks from childhood to adulthood, a better understanding of the relationship between movement behaviors (physical activity, sedentary behavior and sleep) and cardio-metabolic risk in childhood may aid in preventing metabolic syndrome (MetS) in adulthood.

Objective: To examine independent and combined cross-sectional and longitudinal associations between movement behaviors and the MetS score in 8-11 year old Danish children.

Design: Physical activity, sedentary time and sleep duration (seven days and eight nights) were assessed by accelerometer and fat mass index (fat mass/height2) was assessed using Dual-energy X-ray absorptiometry. The MetS-score was based on z-scores of waist circumference, mean arterial blood pressure, homeostatic model assessment of insulin resistance, triglycerides and high density lipoprotein cholesterol. All measurements were taken at three time points separated by 100 days. Average of the three measurements was used as habitual behavior in the cross-sectional analysis and changes from first to third measurement was used in the longitudinal analysis.

Results: 723 children were included. In the cross-sectional analysis, physical activity was negatively associated with the MetS-score (P<0.03). In the longitudinal analysis, low physical activity and high sedentary time were associated with an increased MetS-score (all P<0.005); however, after mutual adjustments for movement behaviors, physical activity and sleep duration, but not sedentary time, were associated with the MetS-score (all P<0.03). Further adjusting for fat mass index while removing waist circumference from the MetS-score rendered the associations no longer statistically significant (all P>0.17). Children in the most favorable tertiles of changes in moderate-to-vigorous physical activity, sleep duration and sedentary time during the 200-day follow-up period had an improved MetS-score relative to children in the opposite tertiles (P = 0.005).

Conclusion: The present findings indicate that physical activity, sedentary time and sleep duration should all be targeted to improve cardio-metabolic risk markers in childhood; this is possibly mediated by adiposity.

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Related in: MedlinePlus

Combined associations between changes in movement behaviors and changes in the metabolic syndrome (MetS) score1 over a 200-day follow-up period in Danish children.Change in movement behaviors between baseline and day 200 was divided into tertiles using the 1st and 3rd tertile as a reference group (REF) and a risk group (RISK). Data are presented as unstandardized regression coefficients (β) with 95% confidence intervals (CI) between reference group and risk group using a linear mixed model. Sleep, sleep duration (RISK<−24.8 vs. REF>−5.5 min/night); SED, sedentary time (RISK>1.6 vs. REF<−3.4%); MVPA, moderate-to-vigorous physical activity (RISK<0.3 vs. REF>15.2 min/day). Adjusted for days of follow up 1MetS-score = (age, sex, pubertal status and sex-pubertal status interaction standardised z-scores of) waist circumference+MAP+HOMAIR+triglycerides – HDL-C. *P = 0.001 to 0.009.
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pone-0104677-g001: Combined associations between changes in movement behaviors and changes in the metabolic syndrome (MetS) score1 over a 200-day follow-up period in Danish children.Change in movement behaviors between baseline and day 200 was divided into tertiles using the 1st and 3rd tertile as a reference group (REF) and a risk group (RISK). Data are presented as unstandardized regression coefficients (β) with 95% confidence intervals (CI) between reference group and risk group using a linear mixed model. Sleep, sleep duration (RISK<−24.8 vs. REF>−5.5 min/night); SED, sedentary time (RISK>1.6 vs. REF<−3.4%); MVPA, moderate-to-vigorous physical activity (RISK<0.3 vs. REF>15.2 min/day). Adjusted for days of follow up 1MetS-score = (age, sex, pubertal status and sex-pubertal status interaction standardised z-scores of) waist circumference+MAP+HOMAIR+triglycerides – HDL-C. *P = 0.001 to 0.009.

Mentions: The combined associations between tertiles of changes in movement behaviors and the MetS-score during the follow-up period are shown in Figure 1. Children in the most favorable tertiles of changes in MVPA, sleep duration and sedentary time had a decrease in the MetS-score of 3.31 (95% CI 1.02;5.61, P = 0.005) relative to children in the opposite tertiles. Mean (SD) change in the MetS-score was −0.04 (3.82). The change in MetS-score between the most favorable and least favorable tertile of movement behavior was due to a difference of 0.54 (95% CI 0.001;1.08; P = 0.049) in HOMAIR and −0.14 mmol/L (95% CI −0.24;−0.04, P = 0.008) in HDL-C but no differences in waist circumference [1.0 cm (95% CI −0.5;2.4, P = 0.19)], triglycerides [0.15 mmol/L (95% CI −0.08;0.37, P = 0.20)] and MAP [0.52 mm Hg (95% CI −2.86;3.89, P = 0.76)].


Low physical activity level and short sleep duration are associated with an increased cardio-metabolic risk profile: a longitudinal study in 8-11 year old Danish children.

Hjorth MF, Chaput JP, Damsgaard CT, Dalskov SM, Andersen R, Astrup A, Michaelsen KF, Tetens I, Ritz C, Sjödin A - PLoS ONE (2014)

Combined associations between changes in movement behaviors and changes in the metabolic syndrome (MetS) score1 over a 200-day follow-up period in Danish children.Change in movement behaviors between baseline and day 200 was divided into tertiles using the 1st and 3rd tertile as a reference group (REF) and a risk group (RISK). Data are presented as unstandardized regression coefficients (β) with 95% confidence intervals (CI) between reference group and risk group using a linear mixed model. Sleep, sleep duration (RISK<−24.8 vs. REF>−5.5 min/night); SED, sedentary time (RISK>1.6 vs. REF<−3.4%); MVPA, moderate-to-vigorous physical activity (RISK<0.3 vs. REF>15.2 min/day). Adjusted for days of follow up 1MetS-score = (age, sex, pubertal status and sex-pubertal status interaction standardised z-scores of) waist circumference+MAP+HOMAIR+triglycerides – HDL-C. *P = 0.001 to 0.009.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125285&req=5

pone-0104677-g001: Combined associations between changes in movement behaviors and changes in the metabolic syndrome (MetS) score1 over a 200-day follow-up period in Danish children.Change in movement behaviors between baseline and day 200 was divided into tertiles using the 1st and 3rd tertile as a reference group (REF) and a risk group (RISK). Data are presented as unstandardized regression coefficients (β) with 95% confidence intervals (CI) between reference group and risk group using a linear mixed model. Sleep, sleep duration (RISK<−24.8 vs. REF>−5.5 min/night); SED, sedentary time (RISK>1.6 vs. REF<−3.4%); MVPA, moderate-to-vigorous physical activity (RISK<0.3 vs. REF>15.2 min/day). Adjusted for days of follow up 1MetS-score = (age, sex, pubertal status and sex-pubertal status interaction standardised z-scores of) waist circumference+MAP+HOMAIR+triglycerides – HDL-C. *P = 0.001 to 0.009.
Mentions: The combined associations between tertiles of changes in movement behaviors and the MetS-score during the follow-up period are shown in Figure 1. Children in the most favorable tertiles of changes in MVPA, sleep duration and sedentary time had a decrease in the MetS-score of 3.31 (95% CI 1.02;5.61, P = 0.005) relative to children in the opposite tertiles. Mean (SD) change in the MetS-score was −0.04 (3.82). The change in MetS-score between the most favorable and least favorable tertile of movement behavior was due to a difference of 0.54 (95% CI 0.001;1.08; P = 0.049) in HOMAIR and −0.14 mmol/L (95% CI −0.24;−0.04, P = 0.008) in HDL-C but no differences in waist circumference [1.0 cm (95% CI −0.5;2.4, P = 0.19)], triglycerides [0.15 mmol/L (95% CI −0.08;0.37, P = 0.20)] and MAP [0.52 mm Hg (95% CI −2.86;3.89, P = 0.76)].

Bottom Line: In the cross-sectional analysis, physical activity was negatively associated with the MetS-score (P<0.03).Further adjusting for fat mass index while removing waist circumference from the MetS-score rendered the associations no longer statistically significant (all P>0.17).Children in the most favorable tertiles of changes in moderate-to-vigorous physical activity, sleep duration and sedentary time during the 200-day follow-up period had an improved MetS-score relative to children in the opposite tertiles (P = 0.005).

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

Background: As cardio-metabolic risk tracks from childhood to adulthood, a better understanding of the relationship between movement behaviors (physical activity, sedentary behavior and sleep) and cardio-metabolic risk in childhood may aid in preventing metabolic syndrome (MetS) in adulthood.

Objective: To examine independent and combined cross-sectional and longitudinal associations between movement behaviors and the MetS score in 8-11 year old Danish children.

Design: Physical activity, sedentary time and sleep duration (seven days and eight nights) were assessed by accelerometer and fat mass index (fat mass/height2) was assessed using Dual-energy X-ray absorptiometry. The MetS-score was based on z-scores of waist circumference, mean arterial blood pressure, homeostatic model assessment of insulin resistance, triglycerides and high density lipoprotein cholesterol. All measurements were taken at three time points separated by 100 days. Average of the three measurements was used as habitual behavior in the cross-sectional analysis and changes from first to third measurement was used in the longitudinal analysis.

Results: 723 children were included. In the cross-sectional analysis, physical activity was negatively associated with the MetS-score (P<0.03). In the longitudinal analysis, low physical activity and high sedentary time were associated with an increased MetS-score (all P<0.005); however, after mutual adjustments for movement behaviors, physical activity and sleep duration, but not sedentary time, were associated with the MetS-score (all P<0.03). Further adjusting for fat mass index while removing waist circumference from the MetS-score rendered the associations no longer statistically significant (all P>0.17). Children in the most favorable tertiles of changes in moderate-to-vigorous physical activity, sleep duration and sedentary time during the 200-day follow-up period had an improved MetS-score relative to children in the opposite tertiles (P = 0.005).

Conclusion: The present findings indicate that physical activity, sedentary time and sleep duration should all be targeted to improve cardio-metabolic risk markers in childhood; this is possibly mediated by adiposity.

Show MeSH
Related in: MedlinePlus