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Fatal melioidosis in goats in Bangkok, Thailand.

Tonpitak W, Sornklien C, Chawanit M, Pavasutthipaisit S, Wuthiekanun V, Hantrakun V, Amornchai P, Thaipadungpanit J, Day NP, Yingst S, Peacock SJ, Limmathurotsakul D - Am. J. Trop. Med. Hyg. (2014)

Bottom Line: Half of them were born and reared in the city.Multilocus sequence typing ruled out an outbreak.This finding challenges the assumption that melioidosis is rarely acquired in central Thailand.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Ruminant Clinic and Department of Pathology, Faculty of Veterinary Medicine, Mahanakorn University of Technology, Bangkok, Thailand; Mahidol-Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology and Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Department of Epidemiology and Diseases Surveillance, Armed Force Research Institute of Medical Science, Bangkok, Thailand; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

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Hemotoxyin and eosin–stained tissue from lung (A) and kidney (B) of goats with melioidosis, showing multinucleated giant cells (black arrows) (original magnification ×400).
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Figure 1: Hemotoxyin and eosin–stained tissue from lung (A) and kidney (B) of goats with melioidosis, showing multinucleated giant cells (black arrows) (original magnification ×400).

Mentions: Histopathologic examination of the heart, lung, liver, spleen and kidney was conducted for four cases (cases 5, 7, 8, and 10). Acute necrotizing and granulomatous inflammation was found in the lung, liver, spleen and kidney in all four cases, and myocardial and endocardial hemorrhage was observed in three cases (cases 7, 8, and 10). Multinucleated giant cells were observed in the lung and spleen in one case (case 8) (Figure 1).


Fatal melioidosis in goats in Bangkok, Thailand.

Tonpitak W, Sornklien C, Chawanit M, Pavasutthipaisit S, Wuthiekanun V, Hantrakun V, Amornchai P, Thaipadungpanit J, Day NP, Yingst S, Peacock SJ, Limmathurotsakul D - Am. J. Trop. Med. Hyg. (2014)

Hemotoxyin and eosin–stained tissue from lung (A) and kidney (B) of goats with melioidosis, showing multinucleated giant cells (black arrows) (original magnification ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125250&req=5

Figure 1: Hemotoxyin and eosin–stained tissue from lung (A) and kidney (B) of goats with melioidosis, showing multinucleated giant cells (black arrows) (original magnification ×400).
Mentions: Histopathologic examination of the heart, lung, liver, spleen and kidney was conducted for four cases (cases 5, 7, 8, and 10). Acute necrotizing and granulomatous inflammation was found in the lung, liver, spleen and kidney in all four cases, and myocardial and endocardial hemorrhage was observed in three cases (cases 7, 8, and 10). Multinucleated giant cells were observed in the lung and spleen in one case (case 8) (Figure 1).

Bottom Line: Half of them were born and reared in the city.Multilocus sequence typing ruled out an outbreak.This finding challenges the assumption that melioidosis is rarely acquired in central Thailand.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, Ruminant Clinic and Department of Pathology, Faculty of Veterinary Medicine, Mahanakorn University of Technology, Bangkok, Thailand; Mahidol-Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology and Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Department of Epidemiology and Diseases Surveillance, Armed Force Research Institute of Medical Science, Bangkok, Thailand; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

Show MeSH
Related in: MedlinePlus