Limits...
Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis.

Zhang ZY, Li C, Zug C, Schluesener HJ - PLoS ONE (2014)

Bottom Line: Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities.Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment.Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.

ABSTRACT
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment of neurodegenerative disorders, including Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. Potential therapeutic effects of Icariin were investigated in an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mouse. Icariin was suspended in carboxymethylcellulose and given orally to APP/PS1 mice. Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment. Following an oral treatment of 10 days, Icariin significantly attenuated Aβ deposition, microglial activation and TGF-β1 immunoreactivity at amyloid plaques in cortex and hippocampus of transgenic mice 5 months of age, and restored impaired nesting ability. Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

Show MeSH

Related in: MedlinePlus

Effect of Icariin on impaired nesting ability.Therapeutic effects of Icariin were monitored using a nesting assay before and during the experimental treatment. Nest construction was explored with paper towel material using a 3 point scaling system in APP/PS1 mice. A: A significant difference between treatment and control group was observed after a 10-days treatment, namely at Day 11. B: No significant difference between the Icariin treatment and the control group could be observed right at the beginning of treatment, namely at Day 1.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4125230&req=5

pone-0104616-g002: Effect of Icariin on impaired nesting ability.Therapeutic effects of Icariin were monitored using a nesting assay before and during the experimental treatment. Nest construction was explored with paper towel material using a 3 point scaling system in APP/PS1 mice. A: A significant difference between treatment and control group was observed after a 10-days treatment, namely at Day 11. B: No significant difference between the Icariin treatment and the control group could be observed right at the beginning of treatment, namely at Day 1.

Mentions: A significant difference between treatment and control groups of these age- and gender-matched APP/PS1 mice was already observed at Day 11, after 10 days of treatment (control = 1.5±0.1, Icariin = 2.1±0.2, p<0.05, n = 6) (Figure 2A). In the Icariin treatment group, relatively immediate chewing and tearing of the paper towels were observed; paper towels were torn into pieces and grouped into a corner of the cage. In contrast, transgenic mice from the control group investigated and slightly chew but did not really destruct the paper towels; paper towels were found all over in the cage, not grouped or not in the corners. As a control, no significant difference between treatment and control groups could be observed right at the beginning of treatment, namely at Day 1 (control = 1.4±0.1, Icariin = 1.5±0.2, p>0.5, n = 6) (Figure 2B).


Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis.

Zhang ZY, Li C, Zug C, Schluesener HJ - PLoS ONE (2014)

Effect of Icariin on impaired nesting ability.Therapeutic effects of Icariin were monitored using a nesting assay before and during the experimental treatment. Nest construction was explored with paper towel material using a 3 point scaling system in APP/PS1 mice. A: A significant difference between treatment and control group was observed after a 10-days treatment, namely at Day 11. B: No significant difference between the Icariin treatment and the control group could be observed right at the beginning of treatment, namely at Day 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125230&req=5

pone-0104616-g002: Effect of Icariin on impaired nesting ability.Therapeutic effects of Icariin were monitored using a nesting assay before and during the experimental treatment. Nest construction was explored with paper towel material using a 3 point scaling system in APP/PS1 mice. A: A significant difference between treatment and control group was observed after a 10-days treatment, namely at Day 11. B: No significant difference between the Icariin treatment and the control group could be observed right at the beginning of treatment, namely at Day 1.
Mentions: A significant difference between treatment and control groups of these age- and gender-matched APP/PS1 mice was already observed at Day 11, after 10 days of treatment (control = 1.5±0.1, Icariin = 2.1±0.2, p<0.05, n = 6) (Figure 2A). In the Icariin treatment group, relatively immediate chewing and tearing of the paper towels were observed; paper towels were torn into pieces and grouped into a corner of the cage. In contrast, transgenic mice from the control group investigated and slightly chew but did not really destruct the paper towels; paper towels were found all over in the cage, not grouped or not in the corners. As a control, no significant difference between treatment and control groups could be observed right at the beginning of treatment, namely at Day 1 (control = 1.4±0.1, Icariin = 1.5±0.2, p>0.5, n = 6) (Figure 2B).

Bottom Line: Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities.Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment.Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.

ABSTRACT
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment of neurodegenerative disorders, including Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. Potential therapeutic effects of Icariin were investigated in an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mouse. Icariin was suspended in carboxymethylcellulose and given orally to APP/PS1 mice. Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment. Following an oral treatment of 10 days, Icariin significantly attenuated Aβ deposition, microglial activation and TGF-β1 immunoreactivity at amyloid plaques in cortex and hippocampus of transgenic mice 5 months of age, and restored impaired nesting ability. Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

Show MeSH
Related in: MedlinePlus