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Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis.

Zhang ZY, Li C, Zug C, Schluesener HJ - PLoS ONE (2014)

Bottom Line: Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities.Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment.Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.

ABSTRACT
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment of neurodegenerative disorders, including Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. Potential therapeutic effects of Icariin were investigated in an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mouse. Icariin was suspended in carboxymethylcellulose and given orally to APP/PS1 mice. Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment. Following an oral treatment of 10 days, Icariin significantly attenuated Aβ deposition, microglial activation and TGF-β1 immunoreactivity at amyloid plaques in cortex and hippocampus of transgenic mice 5 months of age, and restored impaired nesting ability. Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

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Molecular structure of Icariin.
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pone-0104616-g001: Molecular structure of Icariin.

Mentions: Icariin is a natural flavonoid extracted from the Chinese tonic herb Epimedium and is considered the major pharmacologically active compound. Multi-functional Icariin possesses anti-tumor, anti-oxidant, vasorelaxant, anti-bacterial and anti-inflammatory activities [1] (Figure 1). Previous studies reported that Icariin ameliorated brain dysfunction induced by LPS [2], inhibited corticosterone-induced apoptosis in neurons [3], attenuated the ischemia/reperfusion damage to neurons [4], stimulated neurite growth [5] and thereby showed anti-neuroinflammatory and neuroprotective activities. Further, Icariin shows antidepressant-like activity [6]; protects against aluminium-induced learning and memory deficits due to its antioxidant activities; decreases Aβ1-40 content in the hippocampus of aluminium-intoxicated rodents [7]; and its metabolite Icaritin has neuroprotective effects on β amyloid-induced neurotoxicity to neuronal cells [8]. Therefore, Icariin is considered as a potential therapy against neurodegenerative diseases such as Alzheimer's disease (AD).


Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis.

Zhang ZY, Li C, Zug C, Schluesener HJ - PLoS ONE (2014)

Molecular structure of Icariin.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4125230&req=5

pone-0104616-g001: Molecular structure of Icariin.
Mentions: Icariin is a natural flavonoid extracted from the Chinese tonic herb Epimedium and is considered the major pharmacologically active compound. Multi-functional Icariin possesses anti-tumor, anti-oxidant, vasorelaxant, anti-bacterial and anti-inflammatory activities [1] (Figure 1). Previous studies reported that Icariin ameliorated brain dysfunction induced by LPS [2], inhibited corticosterone-induced apoptosis in neurons [3], attenuated the ischemia/reperfusion damage to neurons [4], stimulated neurite growth [5] and thereby showed anti-neuroinflammatory and neuroprotective activities. Further, Icariin shows antidepressant-like activity [6]; protects against aluminium-induced learning and memory deficits due to its antioxidant activities; decreases Aβ1-40 content in the hippocampus of aluminium-intoxicated rodents [7]; and its metabolite Icaritin has neuroprotective effects on β amyloid-induced neurotoxicity to neuronal cells [8]. Therefore, Icariin is considered as a potential therapy against neurodegenerative diseases such as Alzheimer's disease (AD).

Bottom Line: Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities.Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment.Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunopathology of the Nervous System, Institute of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.

ABSTRACT
Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment of neurodegenerative disorders, including Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. Potential therapeutic effects of Icariin were investigated in an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mouse. Icariin was suspended in carboxymethylcellulose and given orally to APP/PS1 mice. Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment. Following an oral treatment of 10 days, Icariin significantly attenuated Aβ deposition, microglial activation and TGF-β1 immunoreactivity at amyloid plaques in cortex and hippocampus of transgenic mice 5 months of age, and restored impaired nesting ability. Our results suggest that Icariin might be considered a promising therapeutic option for human AD.

Show MeSH
Related in: MedlinePlus