Mapping track density changes in nigrostriatal and extranigral pathways in Parkinson's disease.
Bottom Line: Twenty-seven non-demented Parkinson's patients (mean disease duration: 5 years, mean score on the Hoehn & Yahr scale=1.5) were compared with 26 elderly controls matched for age, sex, and education level.Statistically significant increases in track density were found in the Parkinson's patients, relative to controls.The results identified in brainstem and nigrostriatal pathways show a large overlap with the known distribution of neuropathological changes in non-demented PD patients.
Affiliation: Cyclotron Research Centre, University of Liège, Liège, Belgium.Show MeSH
Related in: MedlinePlus
Mentions: Statistically significant increases in track density in Parkinson's disease, relative to controls, were found in brainstem and extrapyramidal motor networks, limbic, and cognitive circuits. Areas of increased TDI were strikingly symmetric between hemispheres. Fig. 1 shows axial slices of the population mean MT image, with the clusters containing significantly increased TDI overlaid. There were no statistically significant decreases in track density in the Parkinson's patients, compared to controls. To clarify the widely distributed but significant results, we lowered the statistical threshold to 0.01 (family-wise error rate corrected). The percent signal change in PD for clusters significant at pFWE < 0.01 is documented in Table 2.
Affiliation: Cyclotron Research Centre, University of Liège, Liège, Belgium.