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IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in Chinese Han population.

Wu HH, Liu NJ, Yang Z, Tao XM, Du YP, Wang XC, Lu B, Zhang ZY, Hu RM, Wen J - Eur. J. Med. Res. (2014)

Bottom Line: Gene and environment interaction analysis was performed by using multiple logistic regression models.The repeatedly confirmed association between IGF2BP2 (rs4402960) and T2DM had not been replicated in this cohort (P = 0.182).Interestingly, we found that obese subjects (body mass index (BMI) ≥ 28.0 kg/m2) bearing the minor A allele had an increased risk to develop T2DM (P = 0.008 for allele analysis and P < 0.001 for genotype analysis).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No, 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040, China. wenjie065@126.com.

ABSTRACT

Background: The objective of this study was to systematically evaluate the contribution of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to type 2 diabetes mellitus (T2DM) and its interaction with obesity to T2DM susceptibility.

Methods: To clarify whether IGF2BP2 is an independent risk factor for T2DM in Chinese population, we conducted a study with a total of 2,301 Chinese Han subjects, including 1,166 T2DM patients and 1,135 controls, for the genotype of a most common and widely studied polymorphism-rs4402960 of IGF2BP2. Genotyping was performed by iPLEX technology. Gene and environment interaction analysis was performed by using multiple logistic regression models.

Results: The repeatedly confirmed association between IGF2BP2 (rs4402960) and T2DM had not been replicated in this cohort (P = 0.182). Interestingly, we found that obese subjects (body mass index (BMI) ≥ 28.0 kg/m2) bearing the minor A allele had an increased risk to develop T2DM (P = 0.008 for allele analysis and P < 0.001 for genotype analysis).

Conclusions: The present study provided data suggesting that the wild C allele of IGF2BP2 (rs4402960) had a protective effect against T2DM in obese subjects of Chinese Han population.

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The interaction analysis of BMI and SNP (rs4402960 with the C/A allele) for diabetes.
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Figure 1: The interaction analysis of BMI and SNP (rs4402960 with the C/A allele) for diabetes.

Mentions: In the model of rs440296 with the allele variable, MLR models were developed to include two main effect variables: BMI and rs4402960. The interaction item among them was detected in the MLR model after adjustment for relevant potential confounders (P = 0.023, Table 3 and Figure 1), and the interaction effect was also estimated (ORInt = 1.603, 95% CI 1.068–2.405). In another model of rs440296 with the genotype variable, the interaction term of BMI and rs4402960 was detected by the same method (P = 0.001, Table 4 and Figure 2), as well as the interaction effect (ORInt = 1.661, 95% CI 1.235–2.233). In these two models, MLR models signified that BMI was a significant and independent risk factor for T2DM, while rs4402960 alone was not significantly associated with T2DM. The interaction terms of BMI and SNP rs4402960 which were detected in the two models only confirmed a significant association between this SNP and T2DM in the high-BMI group (P = 0.008 for allele analysis and P < 0.001 for genotype analysis, data not shown).


IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in Chinese Han population.

Wu HH, Liu NJ, Yang Z, Tao XM, Du YP, Wang XC, Lu B, Zhang ZY, Hu RM, Wen J - Eur. J. Med. Res. (2014)

The interaction analysis of BMI and SNP (rs4402960 with the C/A allele) for diabetes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4121008&req=5

Figure 1: The interaction analysis of BMI and SNP (rs4402960 with the C/A allele) for diabetes.
Mentions: In the model of rs440296 with the allele variable, MLR models were developed to include two main effect variables: BMI and rs4402960. The interaction item among them was detected in the MLR model after adjustment for relevant potential confounders (P = 0.023, Table 3 and Figure 1), and the interaction effect was also estimated (ORInt = 1.603, 95% CI 1.068–2.405). In another model of rs440296 with the genotype variable, the interaction term of BMI and rs4402960 was detected by the same method (P = 0.001, Table 4 and Figure 2), as well as the interaction effect (ORInt = 1.661, 95% CI 1.235–2.233). In these two models, MLR models signified that BMI was a significant and independent risk factor for T2DM, while rs4402960 alone was not significantly associated with T2DM. The interaction terms of BMI and SNP rs4402960 which were detected in the two models only confirmed a significant association between this SNP and T2DM in the high-BMI group (P = 0.008 for allele analysis and P < 0.001 for genotype analysis, data not shown).

Bottom Line: Gene and environment interaction analysis was performed by using multiple logistic regression models.The repeatedly confirmed association between IGF2BP2 (rs4402960) and T2DM had not been replicated in this cohort (P = 0.182).Interestingly, we found that obese subjects (body mass index (BMI) ≥ 28.0 kg/m2) bearing the minor A allele had an increased risk to develop T2DM (P = 0.008 for allele analysis and P < 0.001 for genotype analysis).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No, 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040, China. wenjie065@126.com.

ABSTRACT

Background: The objective of this study was to systematically evaluate the contribution of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to type 2 diabetes mellitus (T2DM) and its interaction with obesity to T2DM susceptibility.

Methods: To clarify whether IGF2BP2 is an independent risk factor for T2DM in Chinese population, we conducted a study with a total of 2,301 Chinese Han subjects, including 1,166 T2DM patients and 1,135 controls, for the genotype of a most common and widely studied polymorphism-rs4402960 of IGF2BP2. Genotyping was performed by iPLEX technology. Gene and environment interaction analysis was performed by using multiple logistic regression models.

Results: The repeatedly confirmed association between IGF2BP2 (rs4402960) and T2DM had not been replicated in this cohort (P = 0.182). Interestingly, we found that obese subjects (body mass index (BMI) ≥ 28.0 kg/m2) bearing the minor A allele had an increased risk to develop T2DM (P = 0.008 for allele analysis and P < 0.001 for genotype analysis).

Conclusions: The present study provided data suggesting that the wild C allele of IGF2BP2 (rs4402960) had a protective effect against T2DM in obese subjects of Chinese Han population.

Show MeSH
Related in: MedlinePlus