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Selenopeptide transamidation and metathesis.

Ollivier N, Blanpain A, Boll E, Raibaut L, Drobecq H, Melnyk O - Org. Lett. (2014)

Bottom Line: Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst.Similar conditions also catalyze the metathesis of selenopeptides.The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.

View Article: PubMed Central - PubMed

Affiliation: CNRS UMR 8161, Institut Pasteur de Lille, Université Lille Nord de France , 59021 Lille, France.

ABSTRACT
Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.

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Related in: MedlinePlus

Transamidationof C-Terminal Sec Peptides 3
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sch3: Transamidationof C-Terminal Sec Peptides 3


Selenopeptide transamidation and metathesis.

Ollivier N, Blanpain A, Boll E, Raibaut L, Drobecq H, Melnyk O - Org. Lett. (2014)

Transamidationof C-Terminal Sec Peptides 3
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120982&req=5

sch3: Transamidationof C-Terminal Sec Peptides 3
Bottom Line: Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst.Similar conditions also catalyze the metathesis of selenopeptides.The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.

View Article: PubMed Central - PubMed

Affiliation: CNRS UMR 8161, Institut Pasteur de Lille, Université Lille Nord de France , 59021 Lille, France.

ABSTRACT
Selenopeptides can be transamidated by cysteinyl peptides in water using mild conditions (pH 5.5, 37 °C) in the presence of an arylthiol catalyst. Similar conditions also catalyze the metathesis of selenopeptides. The usefulness of the selenophosphine derived from TCEP (TCEP═Se) for inhibiting the TCEP-induced deselenization of selenocysteine residue is also reported.

Show MeSH
Related in: MedlinePlus