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A rare cause of testicular metastasis: upper tract urothelial carcinoma.

Manav AN, Kazan E, Ertek MŞ, Amasyalı AS, Culhacı N, Erol H - Case Rep Urol (2014)

Bottom Line: Two-thirds of upper tract urothelial carcinoma (UTUC) is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone.We report a rare case of metastatic UTUC to the testis which has not been reported before, except one case in the literature.Testicular metastasis of UC should be considered in patients with hematuria and testicular swelling.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, School of Medicine, Adnan Menderes University, 09100 Aydın, Turkey.

ABSTRACT
Metastatic testicular cancers are rare. Primary tumor sources are prostate, lung, and gastrointestinal tract for metastatic testicular cancers. Metastasis of urothelial carcinoma (UC) to the testis is extremely rare. Two-thirds of upper tract urothelial carcinoma (UTUC) is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone. We report a rare case of metastatic UTUC to the testis which has not been reported before, except one case in the literature. Testicular metastasis of UC should be considered in patients with hematuria and testicular swelling.

No MeSH data available.


Related in: MedlinePlus

Histopathologic findings of UC metastasis to the left testis ((a) hematoxylin and eosin x20 and (b) cytokeratin x10).
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fig3: Histopathologic findings of UC metastasis to the left testis ((a) hematoxylin and eosin x20 and (b) cytokeratin x10).

Mentions: Cystoscopy revealed a normal bladder and an obstructed left proximal ureter on retrograde pyelography (RGP). The contrast agent could not pass through mid-ureter to proximal segment at RGP. But we could not make differential diagnosis external compression or intraureteral mass for cause of hydronephrosis. Bladder and left ureteral cytology was benign. But we know that urine cytology has low sensitivity for UTUC even for high-grade lesions. After endoscopic investigation, we performed left radical orchiectomy and made a preliminary diagnosis of testicular cancer perioperatively. The pathological result of the left testis was a 3.8 cm malignant epithelial tumor metastasis in the paratesticular area. The tumor included multiple solid areas and lymphovascular, fat, and muscle tissue invasion. The pathology department identified the tumor as the UC metastasis to the left testis (Figure 3). Metastases on the pelvic bone and left sixth rib were revealed by total bone scintigraphy. We thought metastatic UTUC through pathological report, lymph nodes in CT, scintigraphy, and RGP. We planned a systemic gemcitabine-cisplatin chemotherapy regimen.


A rare cause of testicular metastasis: upper tract urothelial carcinoma.

Manav AN, Kazan E, Ertek MŞ, Amasyalı AS, Culhacı N, Erol H - Case Rep Urol (2014)

Histopathologic findings of UC metastasis to the left testis ((a) hematoxylin and eosin x20 and (b) cytokeratin x10).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4120918&req=5

fig3: Histopathologic findings of UC metastasis to the left testis ((a) hematoxylin and eosin x20 and (b) cytokeratin x10).
Mentions: Cystoscopy revealed a normal bladder and an obstructed left proximal ureter on retrograde pyelography (RGP). The contrast agent could not pass through mid-ureter to proximal segment at RGP. But we could not make differential diagnosis external compression or intraureteral mass for cause of hydronephrosis. Bladder and left ureteral cytology was benign. But we know that urine cytology has low sensitivity for UTUC even for high-grade lesions. After endoscopic investigation, we performed left radical orchiectomy and made a preliminary diagnosis of testicular cancer perioperatively. The pathological result of the left testis was a 3.8 cm malignant epithelial tumor metastasis in the paratesticular area. The tumor included multiple solid areas and lymphovascular, fat, and muscle tissue invasion. The pathology department identified the tumor as the UC metastasis to the left testis (Figure 3). Metastases on the pelvic bone and left sixth rib were revealed by total bone scintigraphy. We thought metastatic UTUC through pathological report, lymph nodes in CT, scintigraphy, and RGP. We planned a systemic gemcitabine-cisplatin chemotherapy regimen.

Bottom Line: Two-thirds of upper tract urothelial carcinoma (UTUC) is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone.We report a rare case of metastatic UTUC to the testis which has not been reported before, except one case in the literature.Testicular metastasis of UC should be considered in patients with hematuria and testicular swelling.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, School of Medicine, Adnan Menderes University, 09100 Aydın, Turkey.

ABSTRACT
Metastatic testicular cancers are rare. Primary tumor sources are prostate, lung, and gastrointestinal tract for metastatic testicular cancers. Metastasis of urothelial carcinoma (UC) to the testis is extremely rare. Two-thirds of upper tract urothelial carcinoma (UTUC) is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone. We report a rare case of metastatic UTUC to the testis which has not been reported before, except one case in the literature. Testicular metastasis of UC should be considered in patients with hematuria and testicular swelling.

No MeSH data available.


Related in: MedlinePlus