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Schwannoma in the midline of hard palate: a case report and review of literature.

Moradzadeh Khiavi M, Taghavi Zenouz A, Mesgarzadeh AH, Sabetmehr O, Mahmoudi SM, Kouhsoltani M - J Dent Res Dent Clin Dent Prospects (2014)

Bottom Line: It usually occurs in the head and neck; however, it is rare in the oral cavity.The tongue is the most common site of intraoral schwannomas, followed by the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area.Clinical, radiographic and histopathological features along with differential diagnosis and treatment are also discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Associate Professor, Departments of Oral Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.

ABSTRACT
Schwannoma is a benign encapsulated slow-growing tumor that originates from Schwann cells of the peripheral nerve sheath. It usually occurs in the head and neck; however, it is rare in the oral cavity. The tongue is the most common site of intraoral schwannomas, followed by the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area. We report a rare case of schwannoma in the midline of hard palate with ulcerated surface in a 21-year-old male with a two-month history of a painless swelling on his palate. Clinical, radiographic and histopathological features along with differential diagnosis and treatment are also discussed.

No MeSH data available.


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Mentions: A 21-year-old male referred to the Faculty of Dentistry, Tabriz University of Medical Sciences, with a two-month history of an asymptomatic mass in his palate. He had no history of systemic diseases. Extraoral examination revealed no significant signs. There were no palpable lymph nodes. Intraoral examinations revealed a 2×2-cm pedunculated mass in the midline of the palate. The lesion was non-tender and firm in consistency and had an ulcerated yellowish surface in most areas (Figure 1). There were no osseous alterations on occlusal radiographs (Figure 2). Salivary gland tumors and benign mesanchymal lesions were included in the differential diagnosis. Incisional biopsy was performed under local anesthesia. Histopathological evaluation showed proliferation of spindle-shaped cells with palisaded arrangements around the central acellular area in most parts. Areas of less cellularity and less organized portions were also observed (Figure 3). The overlying epithelium had been replaced by a finbrinopurulent membrane. The results of imunohistochemical staining for S-100 protein were positive (Figure 4). According to histopothological and immunohistochemical findings the diagnosis was schwannoma. After one week, complete excision of the lesion was carried out under general anesthesia and the final histopathological diagnosis was schwannoma, too. After 6 months of follow-up there was no recurrence of the lesion (Figure 5).


Schwannoma in the midline of hard palate: a case report and review of literature.

Moradzadeh Khiavi M, Taghavi Zenouz A, Mesgarzadeh AH, Sabetmehr O, Mahmoudi SM, Kouhsoltani M - J Dent Res Dent Clin Dent Prospects (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120904&req=5

Mentions: A 21-year-old male referred to the Faculty of Dentistry, Tabriz University of Medical Sciences, with a two-month history of an asymptomatic mass in his palate. He had no history of systemic diseases. Extraoral examination revealed no significant signs. There were no palpable lymph nodes. Intraoral examinations revealed a 2×2-cm pedunculated mass in the midline of the palate. The lesion was non-tender and firm in consistency and had an ulcerated yellowish surface in most areas (Figure 1). There were no osseous alterations on occlusal radiographs (Figure 2). Salivary gland tumors and benign mesanchymal lesions were included in the differential diagnosis. Incisional biopsy was performed under local anesthesia. Histopathological evaluation showed proliferation of spindle-shaped cells with palisaded arrangements around the central acellular area in most parts. Areas of less cellularity and less organized portions were also observed (Figure 3). The overlying epithelium had been replaced by a finbrinopurulent membrane. The results of imunohistochemical staining for S-100 protein were positive (Figure 4). According to histopothological and immunohistochemical findings the diagnosis was schwannoma. After one week, complete excision of the lesion was carried out under general anesthesia and the final histopathological diagnosis was schwannoma, too. After 6 months of follow-up there was no recurrence of the lesion (Figure 5).

Bottom Line: It usually occurs in the head and neck; however, it is rare in the oral cavity.The tongue is the most common site of intraoral schwannomas, followed by the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area.Clinical, radiographic and histopathological features along with differential diagnosis and treatment are also discussed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Associate Professor, Departments of Oral Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.

ABSTRACT
Schwannoma is a benign encapsulated slow-growing tumor that originates from Schwann cells of the peripheral nerve sheath. It usually occurs in the head and neck; however, it is rare in the oral cavity. The tongue is the most common site of intraoral schwannomas, followed by the floor of the mouth, palate, gingiva, vestibular mucosa, lips and mental nerve area. We report a rare case of schwannoma in the midline of hard palate with ulcerated surface in a 21-year-old male with a two-month history of a painless swelling on his palate. Clinical, radiographic and histopathological features along with differential diagnosis and treatment are also discussed.

No MeSH data available.


Related in: MedlinePlus