Limits...
Functional MRI activation in white matter during the Symbol Digit Modalities Test.

Gawryluk JR, Mazerolle EL, Beyea SD, D'Arcy RC - Front Hum Neurosci (2014)

Bottom Line: A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function.The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).Future work should focus on evaluating patients with WM dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology/Neuroscience, University of Victoria Victoria, BC, Canada.

ABSTRACT

Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.

Results: RESULTS from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).

Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction.

No MeSH data available.


(A) Corpus callosum activation (circled in yellow) and (B) internal capsule activation (circled in yellow) at the group level (N = 17) during the SDMT. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 3.0 to more clearly depict the activation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4120763&req=5

Figure 3: (A) Corpus callosum activation (circled in yellow) and (B) internal capsule activation (circled in yellow) at the group level (N = 17) during the SDMT. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 3.0 to more clearly depict the activation.

Mentions: The SDMT task revealed white matter activation at the group level in both the corpus callosum and internal capsule (Figure 3). The gray matter results at the group level mirror those depicted at the individual level (Figure 2).


Functional MRI activation in white matter during the Symbol Digit Modalities Test.

Gawryluk JR, Mazerolle EL, Beyea SD, D'Arcy RC - Front Hum Neurosci (2014)

(A) Corpus callosum activation (circled in yellow) and (B) internal capsule activation (circled in yellow) at the group level (N = 17) during the SDMT. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 3.0 to more clearly depict the activation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120763&req=5

Figure 3: (A) Corpus callosum activation (circled in yellow) and (B) internal capsule activation (circled in yellow) at the group level (N = 17) during the SDMT. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 3.0 to more clearly depict the activation.
Mentions: The SDMT task revealed white matter activation at the group level in both the corpus callosum and internal capsule (Figure 3). The gray matter results at the group level mirror those depicted at the individual level (Figure 2).

Bottom Line: A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function.The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).Future work should focus on evaluating patients with WM dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology/Neuroscience, University of Victoria Victoria, BC, Canada.

ABSTRACT

Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.

Results: RESULTS from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).

Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction.

No MeSH data available.