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Functional MRI activation in white matter during the Symbol Digit Modalities Test.

Gawryluk JR, Mazerolle EL, Beyea SD, D'Arcy RC - Front Hum Neurosci (2014)

Bottom Line: A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function.The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).Future work should focus on evaluating patients with WM dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology/Neuroscience, University of Victoria Victoria, BC, Canada.

ABSTRACT

Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.

Results: RESULTS from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).

Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction.

No MeSH data available.


Activation in white and gray matter during the adapted SDMT overlaid on anatomical data for a representative individual (S3). Activation clusters in the corpus callosum and internal capsule are pointed out in green. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 2.5 to more clearly depict the activation.
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Figure 2: Activation in white and gray matter during the adapted SDMT overlaid on anatomical data for a representative individual (S3). Activation clusters in the corpus callosum and internal capsule are pointed out in green. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 2.5 to more clearly depict the activation.

Mentions: Gray matter activation was observed at the individual level in occipital, parietal, temporal and frontal regions (including regions associated with visual stimulation and motor activation), as well as in the cerebellum. Figure 2 shows whole brain activation results for a representative individual (overlaid on the subject's anatomical).


Functional MRI activation in white matter during the Symbol Digit Modalities Test.

Gawryluk JR, Mazerolle EL, Beyea SD, D'Arcy RC - Front Hum Neurosci (2014)

Activation in white and gray matter during the adapted SDMT overlaid on anatomical data for a representative individual (S3). Activation clusters in the corpus callosum and internal capsule are pointed out in green. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 2.5 to more clearly depict the activation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4120763&req=5

Figure 2: Activation in white and gray matter during the adapted SDMT overlaid on anatomical data for a representative individual (S3). Activation clusters in the corpus callosum and internal capsule are pointed out in green. Images are in radiological view. Activation related to the task is displayed in red-yellow with a Z threshold of 2.5 to more clearly depict the activation.
Mentions: Gray matter activation was observed at the individual level in occipital, parietal, temporal and frontal regions (including regions associated with visual stimulation and motor activation), as well as in the cerebellum. Figure 2 shows whole brain activation results for a representative individual (overlaid on the subject's anatomical).

Bottom Line: A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function.The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).Future work should focus on evaluating patients with WM dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology/Neuroscience, University of Victoria Victoria, BC, Canada.

ABSTRACT

Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.

Results: RESULTS from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).

Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction.

No MeSH data available.