Autologous haematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas: a Cochrane systematic review*.
Bottom Line: The planned and measured primary outcomes were overall survival and treatment-related mortality.The planned and measured secondary outcomes were progression-free survival, grade 3-4 non-haematological toxicity and secondary neoplasia.Treatment-related mortality was reported in 5.1% (15 of 294) transplanted patients.
Affiliation: Children's Hospital, University of Cologne, Cologne, Germany.Show MeSH
Related in: MedlinePlus
Mentions: Figure 1 shows the literature search and study flow. We retrieved 1035 records and evaluated 260 full text papers in detail. We included 62 studies with 294 transplanted patients, 1 RCT with 38 transplanted and 45 non-transplanted patients,21 6 single-arm studies reporting aggregate case series data,22–27 and 55 single-arm studies with individual data. In online registries, we identified 6 studies with a still pending completion and we did not find additional studies in the update search.
Affiliation: Children's Hospital, University of Cologne, Cologne, Germany.